Endometrial Hyperplasia Clinical Trial
Official title:
Prospective Clinical Study of Fertility-sparing Treatment With a Membrane-inhibiting Formula Combined With Oral Progestins for Endometrial Carcinoma and Hyperplasia in Childbearing-age Women
The goal of this clinical trial is to evaluate the effect and adverse side effects of membrane-inhibiting formula plus oral progestins as fertility-preserving treatment in patients with early-stage endometrial cancer and endometrial hyperplasia research questions：When taken with oral progestins, does the drug membrane-inhibiting formula shorten the time required for complete endometrial remission? What medical problems do participants have when taking drug membrane-inhibiting formula plus oral progestins? Efficacy, side effects, recurrence, pregnancy, and time to obtain pregnancy in different molecular classifications of POLE-mutated, mismatch repair-deficient(MMRd), p53 wild type(p53wt), and p53-abnormal(p53abn). Participants will: Take drug membrane-inhibiting formula plus oral progestins every day Visit the clinic once every 3 months for checkups, tests, and hysteroscopy Keep a diary of examination results and pathology
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05378152 -
Assessing the Benefit of Pipelle Biopsy in Patients With Postmenopausal Bleeding and an Atrophic-appearing Cavity
|
N/A | |
| Withdrawn |
NCT00123175 -
Treatment of Endometrial Hyperplasia With an Intrauterine Device (IUD)
|
Phase 1/Phase 2 | |
| Completed |
NCT02100137 -
Women With Asymptomatic Endometrial Hyperplasia
|
N/A | |
| Completed |
NCT00242710 -
Study Evaluating Bazedoxifene/Conjugated Estrogens Combinations In Postmenopausal Women
|
Phase 3 | |
| Not yet recruiting |
NCT04191603 -
TWO DİFFERENT ELECTROSURGERY DEVICES AS MONOPOLAR HOOC AND PLASMAKINETIC BIPOLAR SPATULA EFFECTIVENESS DURING COLPOTOMY
|
N/A | |
| Completed |
NCT03032848 -
Vaginal Estrogens Comparative Trial on Pelvic Organ Prolapse Patients
|
Phase 4 | |
| Completed |
NCT00339651 -
Preliminary Study of Endometrial Hyperplasia Groundwork for a Study to Define Precursors of Endometrial Cancer
|
||
| Recruiting |
NCT01234818 -
Management of Endometrial Hyperplasia With a LNG-IUS: Multicenter Study: KGOG2006
|
Phase 2 | |
| Recruiting |
NCT04362046 -
Fertility Sparing Management of EndomeTrial Cancer and Hyperplasia
|
N/A | |
| Active, not recruiting |
NCT05257057 -
Frequency of Endometrial Cancer Precursors Associated With Lynch Syndrome
|
||
| Completed |
NCT01499602 -
Efficacy of LNG-IUS for Treatment of Non-atypical Endometrial Hyperplasia in Perimenopausal Women
|
N/A | |
| Completed |
NCT00883662 -
Mirena Observational Program
|
N/A | |
| Completed |
NCT01074892 -
A Study Comparing Mirena and Systemic Progestin for Endometrial Hyperplasia
|
Phase 4 | |
| Not yet recruiting |
NCT05903131 -
A Behavioral Intervention to Promote Primary Prevention and Uterine Preservation in Premenopausal Women With Obesity and Endometrial Hyperplasia
|
Phase 2 | |
| Not yet recruiting |
NCT05829460 -
Primary Prevention and Uterine Preservation in Premenopausal Women With Obesity and Endometrial Hyperplasia
|
Phase 2 | |
| Withdrawn |
NCT04897217 -
Levonorgestrel-Releasing Intrauterine System (LNG-IUS) in the Management of Atypical Endometrial Hyperplasia
|
Phase 3 | |
| Recruiting |
NCT03176992 -
Surgicel® & Endometrial Ablation in the Management of Perimenpausal Heavy Menstrual Bleeding
|
Phase 2 | |
| Not yet recruiting |
NCT00919919 -
Efficacy and Tolerability Study of Progesterone Vaginal Tablets (Endometrin®) in Menopausal Women Treated by Estrogen
|
Phase 2 | |
| Recruiting |
NCT03207061 -
Can 3D Ultrasound be Used as an Alternative to MRI to Assess Myometrial Invasion in Endometrial Cancer?
|
N/A | |
| Recruiting |
NCT03207126 -
Pilot Study: Can Ultrasound Guided Biopsy be Used as an Alternative to Hysteroscopy?
|
N/A |