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Clinical Trial Summary

Problem statement: The post-operative pain after endodontic treatment. aim of study: The study is aiming to compare postoperative pain after submucosal cold saline injection (submucosal cryotherapy) (SMC) versus intra-canal cryotherapy (ICC) in mandibular single rooted premolars with symptomatic irreversible pulpitis with symptomatic apical periodontitis (SAP). The material and methods: Subjects and methods: sixty patients will be randomly divided into three groups: the SMC group, the ICC group, and the control group. The patients' postoperative pain will be recorded at 12, 24, and 48 hours postoperatively by questioning them. Quantification of substance P will be done using an ELISA test from peri-radicular fluid swab.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06304259
Study type Interventional
Source October 6 University
Contact Yara Adel, Bds
Phone 00201000099191
Email yara.adel170496@gmail.com
Status Not yet recruiting
Phase N/A
Start date April 2024
Completion date October 1, 2024

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