End Stage Renal Failure Clinical Trial
Official title:
Evaluate the Effects of Turmeric on Oxidative Stress Markers in HD Patients
Despite advances in prevention of cardiovascular diseases, the incidence of accelerated atherosclerosis in hemodialysis (HD) patients has still remained high. Oxidative stress is considered as a major player in uremia associated morbidity and mortality in HD patients. The aim of this study was to evaluate the effects of turmeric on oxidative stress markers in HD patients.
End-stage renal disease (ESRD) is a state of oxidative stress, due to uremic oxidant
mediator's accumulation, the activation of phagocytic oxidative metabolism by the dialysis
membrane, intravenous iron therapy and the antioxidant depletion caused by hemodialysis
(HD). Some trials showed a significant benefit from antioxidant therapy on cardiovascular
outcome in HD patients.
Extensive research focused on direct exogenous antioxidants including vitamin C, and vitamin
E, in the treatment of cardiovascular disease. Some clinical trials showed no more
beneficial effect of exogenous antioxidant supplementation in cardiovascular disease (CVD)
and recommended the necessity for a new approach to regulating cellular redox status.
Turmeric (Curcuma longa Linn) is an herb used as a dietary spice and in traditional medicine
for centuries. Curcumin, the most active and non-toxic component of turmeric, is a
polyphenol, which has been extensively studied for its therapeutic benefits, such as
antioxidant. Besides, turmeric has also been effective in attenuation of proteinurea in
diabetic nephropathy and lupus nephritis patients.
Curcumin restored the activities of mitochondrial enzymes complexes and thereby attenuated
the release of reactive oxygen species. Turmeric appears to be non-toxic to humans even at
high doses. However, there is a paucity of information on the effect of turmeric in HD
population. We have, therefore, followed up this study to determine the beneficial effect of
turmeric on oxidative stress in HD patients.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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