End Stage Renal Failure Clinical Trial
Official title:
Effect of Reducing Phosphorus Absorption on Cardiac Biomarkers in Hemodialysis Patients
Hyperphosphatemia and elevated cardiac biomarkers are two key characteristics of patients in end stage renal diseases(ESRD),however the majority of whom are in the absence of acute coronary syndrome(ACS). And it is still unclear why cardiac biomarkers would increase in those patients. We hypothesized that excessive phosphorus is account for that phenomenon.To confirm that hypothesis,we used one phosphorus binder to reduce phosphorus absorption in hemodialysis patients for some time and observed the change of cardiac biomarkers of those patients.
Cardiovascular disease is one of the leading causes of morbidity and mortality in patient with chronic kidney disease(CKD), accounting for more than 50% of all deaths.When myocardial cells get injured, cardiac biomarkers will be released into the circulation. Elevated cardiac biomarkers have been observed in patients with various degrees of renal failure. However, the majority of those CKD patients are in the absence of acute coronary syndrome. So far, it is still unclear the mechanisms of the increased biomarkers in CKD patients. Meanwhile, hyperphosphatemia is one of the major features of CKD, particularly of end stage renal disease(ESRD). Lots of evidences have shown that high levels of serum phosphorus and an elevation of the serum calcium × phosphorus product can lead to cardiovascular calcifications and subsequent cardiovascular morbidity and mortality in patients with CKD.it is tempting to hypothesize that hyperphosphatemia may be responsible for the rise of cardiac biomarkers in CKD patients.So we use one phosphate binder to reduce phosphorus absorption in hemodialysis patients for one year and observe the change of cardiac biomarkers of those patients. ;
Observational Model: Case Control, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01766882 -
Volume,Sodium and Blood Pressure Management in HD
|
N/A | |
| Completed |
NCT01037595 -
Effect of Turmeric on Pruritus in Hemodialysis Patients
|
Phase 0 | |
| Completed |
NCT02686398 -
Immunogenicity of a Trivalent Influenza Vaccine in Chronic Kidney Disease Patients Undergoing Hemodialysis
|
Phase 4 | |
| Completed |
NCT01990118 -
Gengraf Conversion Study in Stable Renal Allograft Transplant Recipients
|
Phase 4 | |
| Recruiting |
NCT01704313 -
A Trial of Interrupted vs Continuous Suturing Techniques for Radiocephalic Fistulae
|
N/A | |
| Completed |
NCT01004627 -
A Study of Routine Versus Selective Use of Ultrasound Scanning Prior to Haemodialysis Fistula Surgery
|
N/A | |
| Not yet recruiting |
NCT04376567 -
Patient-Centered Outcomes for One-stage and Two-stage Brachial Basilic Arteriovenous Fistulas
|
N/A | |
| Recruiting |
NCT02895425 -
Registry for End Stage Renal Failure
|
N/A | |
| Not yet recruiting |
NCT02341547 -
Effectiveness of a Biosimilar Epoetin Alfa in Stable 'End Stage Renal Failure'
|
N/A | |
| Completed |
NCT01834755 -
Physical and Psychological Profiles Associated With Patient's Preference for ESRD Treatment
|
N/A | |
| Completed |
NCT01101217 -
Effect of Zinc Suplementation on Serum Hemosystein Level in Hemodialysis Patients
|
N/A | |
| Completed |
NCT01996930 -
Steroid Impregnated Tape in the Treatment of Over-granulating Peritoneal Dialysis Exit Sites
|
Phase 3 | |
| Not yet recruiting |
NCT01704339 -
Qutenza for Critical Ischaemia in End Stage Renal Failure
|
Phase 4 | |
| Completed |
NCT01906840 -
Role of Turmeric on Oxidative Modulation in ESRD Patients
|
Phase 1/Phase 2 | |
| Not yet recruiting |
NCT06378931 -
Quality of Life Change in Patients Undergoing Parathyroidectomy With End-stage Renal Failure
|