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Autologous Endothelial Progenitor Cell Therapy for Reversal of Liver Cirrhosis

End Stage Liver Disease Clinical Trial

Official title:
Autologous Endothelial Progenitor Cell Therapy for Reversal of Liver Cirrhosis

Clinical Trial Summary

This proposal translates a hypothesis driven basic research into clinical setting to determine the potential of using autologous CD133+ cells to reverse fibrosis and improve clinical outcome for patients with end stage cirrhosis. This has significant impact on the management of cirrhosis.

Clinical Trial Description

This is a 2 arm randomised study patients with decompensated liver cirrhosis involving minimum of 23 and maximum of 33 patients in each arm. The investigators propose that transplantation of mobilized autologous CD133+ cells harvested from the bone marrow directly into the liver has the ability to replace and regenerate the damaged sinusoidal endothelium as well as normalize macrophage and Natural Killer (NK) cell function. The niche provided by the refenestrated endothelium can polarize the macrophage to antifibrotic phenotype as well as directly inactivate the activated myofibroblast, resulting in reversal of liver fibrosis and improvement in liver function. Transplantation of cells will be via intraportal route delivered by percutaneous cannulation of the portal vein system. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03109236
Study type Interventional
Source National University Hospital, Singapore
Contact Nur Halisah
Phone 66015193
Email mdcnhj@nus.edu.sg
Status Recruiting
Phase Phase 3
Start date August 24, 2017
Completion date December 31, 2023
View Details
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