Hypoxic Pulmonary Vasoconstriction Pilot Study

Status Completed

Clinical Trial Summary

The purpose of this study is to determine if the events leading to smoking-associated centrilobular and paraseptal emphysema are caused by a failure of the lungs' inherent mechanisms to block hypoxic pulmonary vasoconstriction (HPV) in areas of smoking-induced inflammation.

Clinical Trial Description

Overall goals of this study are to 1) determine the effects on sildenafil on the heterogeneity perfused blood volume in smokers susceptible to emphysema using dual energy CT 2) utilize pulmonary blood volume heterogeneity as an image-based biomarker to differentiate normal and susceptible smokers. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03733470
Study type	Interventional
Source	University of Iowa
Contact
Status	Completed
Phase	Phase 4
Start date	June 29, 2011
Completion date	January 13, 2014

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