Emphysema Clinical Trial
Official title:
Study on Phenotypic Characterization of Combined Pulmonary Fibrosis and Emphysema
This study is to evaluate the expression of biological markers in induced sputum and peripheral blood T lymphocytes of patients with combined pulmonary fibrosis and emphysema (CPFE). The features of CPFE would be observed, including pulmonary function tests and fractional exhaled nitric oxide （FENO）.
A new disease including concomitant upper-lobe emphysema and lower-lobe fibrosis in
radiology has been defined as (combined pulmonary fibrosis and emphysema, CPFE). CPFE has
distinct clinical characteristics with the emphysema and the pulmonary fibrosis, including
gender, age, clinical manifestation, pulmonary function tests and prognosis.
Normally Th1/Th2 is balanced. However, patients with emphysema had a significantly higher
expression of Th1. On the other hand, higher expression of Th2 is involved in the
development of pulmonary fibrosis. The expressions of Th1 and Th2 were proved to play a
central role in pathogenesis of emphysema and pulmonary fibrosis, while are still unknown in
patients of combined pulmonary fibrosis and emphysema. The study would observe the Th1/Th2
expression, pulmonary function tests , fractional exhaled nitric oxide （FENO）and other
features in CPFE patients.
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Observational Model: Case Control, Time Perspective: Cross-Sectional
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