Testing a Neurocognitive Model of Distancing Using Transcranial Magnetic Stimulation.

Emotion Regulation Clinical Trial

Official title: Testing a Neurocognitive Model of Distancing Using Transcranial Magnetic Stimulation.

Status Completed

Clinical Trial Summary

Distancing oneself from a current distressing situation is a mental skill that can help people to manage their emotions. However, little is known about how distancing works in the brain. Recently developed tools in neuroscience that can modify brain activity might be able to make distancing more or less effective. In doing so, the results could lead to a better understanding of the cognitive processes and neural circuits that support distancing as a form of emotion regulation. If successful, this research may lead to the development of new treatments to help those who suffer from stress-related disorders, such as anxiety and depression.

Clinical Trial Description

Distancing is an emotion regulation skill that relies in part on self-projection, or the ability to shift perspective from the here and now to a simulated time, place, or person. Based on prior review and meta-analysis of the distancing literature, a new model has been developed of the neurocognitive processes that support distancing. The proposed experiment will test the model causally through a neural intervention that should impair or enhance the ability of healthy adults to successfully apply distancing to down-regulate negative affect. In the model, it is hypothesized that the temporoparietal junction (TPJ) was a key region mediating the self-projection aspect of distancing. Leveraging recent functional magnetic resonance imaging (fMRI) work, the experiment will functionally modulate this region through inhibitory transcranial magnetic stimulation (TMS) to test its causal role in distancing. Importantly, the proposed work shifts emphasis from traditional models of emotion regulation, which implicate frontal executive control mechanisms, to new cognitive processes and brain targets that can ultimately lead to novel approaches to treat affective disorders. ;

Related Conditions & MeSH terms

• Emotion Regulation
• Real Versus Sham Transcranial Magnetic Stimulation (TMS)

• NCT number: NCT03698591
• Study type: Interventional
• Source: Duke University
• Status: Completed
• Phase: N/A
• Start date: October 31, 2018
• Completion date: May 24, 2019