The Association of Cardiac Ion Channel Related Gene Polymorphism and Prolonged QTc Interval After Endotracheal Intubation

Emergence Delirium Clinical Trial

Official title:

The Association of Cardiac Ion Channel Related Gene Polymorphism and Prolonged QTc Interval After Endotracheal Intubation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03788564
• Other study ID #: 4-2017-0727
• Status: Completed
• Start date: September 24, 2017
• Est. completion date: May 3, 2020

Study information

• Verified date: September 2020
• Source: Yonsei University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The QTc interval is affected by heart rate, medications and changes in the autonomic nervous system. The endotracheal laryngoscopy, the necessary step during general anesthesia, prolongs QTc interval. Changes in the flow of ion currents could result from the genetic variation of myocardial ion channels by gene polymorphism. This study is to investigate the association of cardiac ion channel related gene polymorphism and prolonged QTc interval after endotracheal intubation in adult patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 315
• Est. completion date: May 3, 2020
• Est. primary completion date: May 3, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 65 Years

Eligibility

Inclusion Criteria:

1. 20-65 years old

2. scheduled for general anesthesia requiring direct laryngoscopy

Exclusion Criteria:

1. Patients taking antihypertensive medication (beta-blocker, CCB)

2. patients taking other medications known to affect QTc interval

3. Patients with abnormal ECG and prolonged QTc (>500 msec)

4. Diabetes, liver disease, kidney disease, heart failure, congenital heart disease

5. Severe electrolyte imbalance

6. illiterate, foreigners who cannot understand the consent form

Related Conditions & MeSH terms

• Delirium
• Emergence Delirium

Locations

Country	Name	City	State
Korea, Republic of	Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Yonsei University

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	QTc interval	QTc interval prolongs followed by laryngoscopy due to changes in the autonomic nervous system. The restoration of the prolonged QTc could also be affected by the balance of autonomic nervous system or changes in the related cardiac ion channels.	Before anesthesia, Before laryngoscopy, Right after laryngoscopy, 5 minutes after laryngoscopy