Electroacupuncture Clinical Trial
Official title:
Protective Effect of Electroacupuncture on Lung in Patients Undergoing General Anesthesia
Objective to investigate the protective effect of preoperative electroacupuncture on lung function in patients with mechanical ventilation for more than 2 hours under general anesthesia
Status | Not yet recruiting |
Enrollment | 72 |
Est. completion date | September 1, 2023 |
Est. primary completion date | September 1, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 60 Years |
Eligibility | Inclusion Criteria: - Patients undergoing general anesthesia in our hospital; - Ages 18-60; - American Society of Anesthesiologists (ASA) grade ? ~ III , no severe respiratory, circulation, liver, kidney, coagulation function abnormalities; - Expected duration of operation >2h; - Surgical grade 2-4; - No serious lung infection and lung disease; - Body mass index (BMI) 18~30 kg/m2; There are no contraindications for electroacupuncture stimulation. Exclusion Criteria: - Patients with severe circulatory or other system dysfunction; - Patients with pulmonary and one-lung ventilation; - Unwilling to cooperate with the patient; - Patients with low compliance. |
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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Lingling Ding |
Type | Measure | Description | Time frame | Safety issue |
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Primary | oxygenation index | record oxygenation index | Before anesthesia | |
Primary | oxygenation index | record oxygenation index | 2 hours after tracheal intubation | |
Primary | oxygenation index | record oxygenation index | 5 minutes after tracheal intubation removal | |
Secondary | Postoperative comfort score | Assess the quality of recovery during recovery | during anesthesia recovery period | |
Secondary | sedation score (Ramsay) | Assess the quality of recovery during recovery | during anesthesia recovery period | |
Secondary | restfulness score (DRS) | Assess the quality of recovery during recovery | during anesthesia recovery period | |
Secondary | visual analogue scale (VAS) | Assess the quality of recovery during recovery | during anesthesia recovery period | |
Secondary | Length of stay | Assess the quality of postoperative recovery | 1 week after discharge, the patient's length of stay will be recorded through medical record system | |
Secondary | postoperative time in hospital | Assess the quality of postoperative recovery | 1 week after discharge, the patient's postoperative time in hospital will be recorded through medical record system | |
Secondary | postoperative complications of major organs | Assess the quality of postoperative recovery | Major organ complications during hospitalization,assessed up to 30 days after surgery | |
Secondary | mortality within 30 days | Assess the quality of postoperative recovery | mortality within 30 days will be recorded | |
Secondary | Expression of IL-18 in serum | The perioperative inflammation level will be assessed | Before anesthetic induction the radial artery blood samples will be collected, and the expressions of IL-18 in serum will be detected by flow cytometry | |
Secondary | Expression of IL-18 in serum | The perioperative inflammation level will be assessed | 5minutes after tracheal intubation removal the radial artery blood samples will be collected, and the expressions of IL-18 in serum will be detected by flow cytometry | |
Secondary | Expression of IL-1ß in serum | The perioperative inflammation level will be assessed | Before anesthetic induction the radial artery blood samples will be collected, and the expressions of IL-1ß in serum will be detected by flow cytometry | |
Secondary | Expression of IL-1ß in serum | The perioperative inflammation level will be assessed | 5minutes after tracheal intubation removal the radial artery blood samples will be collected, and the expressions of IL-1ß in serum will be detected by flow cytometry | |
Secondary | Expression of IL-10 in serum | The perioperative inflammation level will be assessed | Before anesthetic induction the radial artery blood samples will be collected, and the expressions of IL-10 in serum will be detected by flow cytometry | |
Secondary | Expression of IL-10 in serum | The perioperative inflammation level will be assessed | 5minutes after tracheal intubation removal the radial artery blood samples will be collected, and the expressions of IL-10 in serum will be detected by flow cytometry | |
Secondary | Mean arterial pressure | Intraoperative vital signs will be recorded | Before anesthesia ,2 hours after tracheal intubation , and 5minutes after tracheal intubation removal | |
Secondary | heart rate | Intraoperative vital signs will be recorded | Before anesthesia , 2 hours after tracheal intubation , and 5minutes after tracheal intubation removal | |
Secondary | BIS | Intraoperative vital signs will be recorded | Before anesthesia , 2 hours after tracheal intubation , and 5minutes after tracheal intubation removal | |
Secondary | extubation time | Intraoperative vital signs will be recorded | Before anesthesia , 2 hours after tracheal intubation , and 5minutes after tracheal intubation removal | |
Secondary | anesthesia dosage | Intraoperative vital signs will be recorded | Before anesthesia , 2 hours after tracheal intubation , and 5minutes after tracheal intubation removal |
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