Elective Cesarean Section Clinical Trial
Official title:
Delayed Cord Clamping in Infants Born by Cesarean Section: a Randomized Controlled Trial
Introduction: Placental transfusion supports an important blood transfer to the neonate,
promoting a more stable and smooth transition from fetal to extra-uterine life. Cesarean
section, especially elective one, reduces the placental transfusion, mainly because of
uterine atony. Therefore, during an elective cesarean section umbilical cord management may
play a relevant role on blood passage to the neonate and, as consequence, it may affect
neonatal hematological values and cardiovascular parameters. The most effective way to manage
umbilical cord in in elective cesarean section remains to be established.
Objective: The aim of the present study is to evaluate the effect of two different methods of
umbilical cord management (Early Cord Clamping - ECC vs. Delayed Cord Clamping - DCC) on the
hematocrit on the second day of life; in addition, we will assess the effect on perinatal and
postnatal cardiovascular parameters.
Material and methods: This is a randomized clinical trial on the effect of different cord
management newborns born by cesarean sections. After obtaining parental consent, all mothers
> 38 weeks' gestation will be assigned to eithr ECC or DCC group in a 1:1 ratio according to
a computer-generated randomized sequence. The primary outcome will be the hematocrit on day 2
of life. Secondary outcomes will be pre-ductal oxygen saturation (SaO2) and the heart rate
(HR) during the first ten minutes after the birth, arterial blood pressures during the first
3 postnatal days and transcutaneous bilirubin (BT) at day 3 after birth.
n/a
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