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Evaluation of the Effects of Cross Linking on the Biomechanical Characteristics of Skin Samples From Patients With Classic or Hypermobile Ehlers-Danlos Syndrome — SEDSKIN  

Ehlers-Danlos Syndrome Clinical Trial

Official title:
Evaluation of the Effects of Cross Linking on the Biomechanical Characteristics of Skin Samples From Patients With Classic or Hypermobile Ehlers-Danlos Syndrome

Clinical Trial Summary

The main aim of this study is to evaluate the effect of cross linking on the elasticity of skin samples from patients with non-vascular Ehlers-Danlos Syndrome (hEDS or cEDS).

Clinical Trial Description

This is a single-center study based on skin biopsies. The skin biopsies will be taken at the non-vascular Ehlers-Danlos syndromes reference center at the Raymond Poincaré Hospital (Garches), by Dr. Karelle Benistan. This center regularly performs this type of biopsy as part of its routine care, and has set up a fibroblast bank for Genethon (Authorization for biological collection at Genethon: SED BACG n° DC-2021-4628). Samples will be transported to the Centre de Recherche Saint-Antoine (UMR-S 938) where they will be processed, cut and placed on histological slides. Atomic force microscopy analyses will be carried out at the Laboratoire de Réactivité de Surface (CNRS/Sorbonne University). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06336473
Study type Interventional
Source GCS Ramsay Santé pour l'Enseignement et la Recherche
Contact Geoffroy NOURISSAT, MD
Phone 07 69 99 67 30
Email gnourissat@wanadoo.fr
Status Not yet recruiting
Phase N/A
Start date April 1, 2024
Completion date July 31, 2025
View Details
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