Ehlers-Danlos Syndrome Clinical Trial
Official title:
Opioid-Free Intravenous Anesthesia for Patients With Joint Hypermobility Syndrome Undergoing Craneo-Cervical Fixation: A Case-series Study Focused on Anti-hyperalgesic Approach
Cranio-cervical instability (CCI) has been well identified in diseases regarding connective tissue, such as Ehlers-Danlos Syndrome/Hipermobility Type (EDS-HT). These patients frequently suffer from severe widespread pain with very difficult management and control. Chronic neuroinflamation, opioid-induced hyperalgesia, and central sensitization phenomena may explain this complex painful condition. A retrospective, observational, consecutive case series study is designed to determine if opioid-free anesthetic management shows a reduction in postoperative pain and opioid rescues needs in comparison with opioid-based anesthesia management for patients with EDS-HT undergoing crano-cervical fixation.
Cranio-cervical instability (CCI) has been well identified in diseases regarding connective
tissue, such as Ehlers-Danlos Syndrome/Hipermobility Type (EDS-HT). These patients frequently
suffer from severe widespread pain with very difficult management and control. Chronic
neuroinflamation, opioid-induced hyperalgesia, and central sensitization phenomena may
explain this complex painful condition. A retrospective, observational, consecutive case
series study is designed to determine if opioid-free anesthetic management shows a reduction
in postoperative pain and opioid rescues needs in comparison with opioid-based anesthesia
management for patients with EDS-HT undergoing craneo-cervical fixation.
Main Aim: To determine if the administration of opioid-free anesthesia with propofol,
lidocaine, ketamine, and dexmedetomidine shows reduction of postoperative pain, and
postoperative needs of opioids rescue in patients undergoing CCF.
Secondary Aims:
- To determine if the administration of opioid-free anesthesia in patients undergoing CCF,
and postoperative Lidocaine, Ketamine, and Dexmedetomidine infusions can reduce the
preoperative needs of opioids treatment at discharge time.
- To determine if the administration of opioid-free anesthesia in patients undergoing CCF
reduces the postoperative gastrointestinal complications.
- To determine if the administration of postoperative Lidocaine, Ketamine, and
Dexmedetomidine infusions in patients underwent CCF can reduce the preoperative needs of
postoperative anxiolytic treatment.
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