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Edwards Syndrome clinical trials

View clinical trials related to Edwards Syndrome.

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NCT ID: NCT02787486 Completed - Down Syndrome Clinical Trials

Expanded Noninvasive Genomic Medical Assessment: The Enigma Study

Start date: October 2015
Phase:
Study type: Observational

In January 2007, the American Congress of Obstetricians and Gynecologists (ACOG) revised its guidelines that now recommend physicians are ethically obligated to fully inform all pregnant women that screening for fetal chromosomal abnormalities including biochemical screening tests and invasive procedures such as CVS or amniocentesis is available, regardless of age. Further, it is entirely up to the patient to decide whether or not she wishes to be screened for fetal chromosomal abnormalities without judgment from the physician. Noninvasive laboratory-developed tests (LDTs) that detect an abnormal amount of maternal and fetal DNA in an expectant mother's blood sample (known as circulating cell-free DNA) are now available. These LDTs have not been cleared or approved by the U.S. Food and Drug Administration (FDA). Although LDTs to date have not been subject to U.S. FDA regulation, certification of the laboratory is required under the Clinical Laboratory Improvement Amendments (CLIA) to ensure the quality and validity of the test. To sample collection study will obtain whole blood specimens from pregnant subjects to be used for development of prenatal assays to assist in the screening for fetal genetic abnormalities, infectious and other diseases, and blood group typing through detection of circulating cell-free DNA extracted from maternal plasma.

NCT ID: NCT01663350 Completed - Pregnancy Clinical Trials

Comparison of Aneuploidy Risk Evaluations

CARE
Start date: July 2012
Phase: N/A
Study type: Observational

This is a prospective, multiā€center observational study designed to compare the test results of the Verinata Health Prenatal Aneuploidy Test to results of conventional prenatal screening for fetal chromosome abnormalities in 'all-risk' pregnancies.

NCT ID: NCT00971334 Completed - Pregnancy Clinical Trials

Noninvasive Screening for Fetal Aneuploidy: A New Maternal Plasma Marker

Start date: August 2009
Phase: N/A
Study type: Observational

The purpose of this study is to collect samples for the purpose of developing a prenatal aneuploid test using circulating cell free fetal (ccff) nucleic acid from blood samples from pregnant women who have a high-risk pregnancy undergoing invasive prenatal diagnosis by chorionic villus sampling (CVS) and/or genetic amniocentesis. The results of the ccff aneuploid test will be compared to the chromosomal analysis obtained via CVS or amniocentesis.

NCT ID: NCT00847990 Completed - Down Syndrome Clinical Trials

Non-Invasive Screening for Fetal Aneuploidy

Start date: March 2009
Phase: N/A
Study type: Observational

The purpose of this study is to determine if a laboratory test developed by the Sequenom Center for Molecular Medicine (SCMM) that uses a new marker found in the mother's blood can better identify pregnancies that have a child with a chromosome abnormality such as Down syndrome (Trisomy 21), Edwards syndrome (Trisomy 18), or other chromosome abnormality.