Clinical Trials Logo

Clinical Trial Details — Status: Active, not recruiting

Administrative data

NCT number NCT03170713
Other study ID # ERZINCAN UNIVERSITY 10
Secondary ID
Status Active, not recruiting
Phase N/A
First received May 20, 2017
Last updated May 26, 2017
Start date May 15, 2017
Est. completion date November 15, 2017

Study information

Verified date May 2017
Source Erzincan University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

this study was planned to investigate the antiinflammatory activity of preemptive intravenous ibuprofen on inflammatory complications such as edema and trismus after third molar tooth surgery


Recruitment information / eligibility

Status Active, not recruiting
Enrollment 60
Est. completion date November 15, 2017
Est. primary completion date October 30, 2017
Accepts healthy volunteers No
Gender All
Age group 20 Years to 35 Years
Eligibility Inclusion Criteria:

- Elective 3. Molar tooth extraction

- Patients between the ages of 20-35

- Patients who are symptomatic

- 3. Molar tooth angular or horizontal settled patients

Exclusion Criteria:

- Patients who refuse to participate in the study

- Patients under 20 years old, over 35 years old

- Patients who are allergic to known non-steroidal anti-inflammatory drugs

- Pregnant patients

- Patients with severe hepatic insufficiency

- Patients with severe renal insufficiency

Study Design


Related Conditions & MeSH terms


Intervention

Drug:
arveles
800 mg ibuprofen and 50 mg dexketoprofen in 150 cc normal saline before operation will be given in 30 minutes. The edema size, mouth opening (trismus) will be recorded in all patients in the preoperative period, postoperative period, postoperative 48th hour and 1 st week.
intrafen
800 mg ibuprofen in 150 cc normal saline before operation will be given in 30 minutes.The edema size, mouth opening (trismus) will be recorded in all patients in the preoperative period, postoperative period, postoperative 48th hour and 1 st week.
Other:
placebos
150 cc normal saline before operation will be given in 30 minutes.The edema size, mouth opening (trismus) will be recorded in all patients in the preoperative period, postoperative period, postoperative 48th hour and 1 st week.

Locations

Country Name City State
Turkey Erzincan University Erzincan

Sponsors (1)

Lead Sponsor Collaborator
Erzincan University

Country where clinical trial is conducted

Turkey, 

References & Publications (10)

Agarwal S, Chattopadhyay S, Mandal M. Comparison of efficacy of aceclofenac and ibuprofen after surgical removal of impacted third molar. J. Evolution Med. Dent. Sci. 2017;6(21):1670-1677, DOI: 10.14260/Jemds/2017/368

Bouloux GF, Steed MB, Perciaccante VJ. Complications of third molar surgery. Oral Maxillofac Surg Clin North Am. 2007 Feb;19(1):117-28, vii. Review. — View Citation

Chukwuneke F, Onyejiaka N. Management of postoperative morbidity after third molar surgery: a review of the literature. Niger J Med. 2007 Apr-Jun;16(2):107-12. Review. — View Citation

Chukwuneke FN, Oji C, Saheeb DB. A comparative study of the effect of using a rubber drain on postoperative discomfort following lower third molar surgery. Int J Oral Maxillofac Surg. 2008 Apr;37(4):341-4. doi: 10.1016/j.ijom.2007.11.016. Epub 2008 Feb 12. — View Citation

Colorado-Bonnin M, Valmaseda-Castellón E, Berini-Aytés L, Gay-Escoda C. Quality of life following lower third molar removal. Int J Oral Maxillofac Surg. 2006 Apr;35(4):343-7. Epub 2005 Nov 8. — View Citation

Jain N, Maria A. Randomized double blind comparative study on the efficacy of Ibuprofen and aceclofenac in controlling post-operative sequelae after third molar surgery. J Maxillofac Oral Surg. 2011 Jun;10(2):118-22. doi: 10.1007/s12663-011-0198-9. Epub 2 — View Citation

Jerjes W, El-Maaytah M, Swinson B, Banu B, Upile T, D'Sa S, Al-Khawalde M, Chaib B, Hopper C. Experience versus complication rate in third molar surgery. Head Face Med. 2006 May 25;2:14. — View Citation

Markovic A, Todorovic Lj. Effectiveness of dexamethasone and low-power laser in minimizing oedema after third molar surgery: a clinical trial. Int J Oral Maxillofac Surg. 2007 Mar;36(3):226-9. Epub 2006 Dec 8. — View Citation

Sato FR, Asprino L, de Araújo DE, de Moraes M. Short-term outcome of postoperative patient recovery perception after surgical removal of third molars. J Oral Maxillofac Surg. 2009 May;67(5):1083-91. doi: 10.1016/j.joms.2008.09.032. — View Citation

Vegas-Bustamante E, Micó-Llorens J, Gargallo-Albiol J, Satorres-Nieto M, Berini-Aytés L, Gay-Escoda C. Efficacy of methylprednisolone injected into the masseter muscle following the surgical extraction of impacted lower third molars. Int J Oral Maxillofac Surg. 2008 Mar;37(3):260-3. doi: 10.1016/j.ijom.2007.07.018. Epub 2008 Mar 4. — View Citation

Outcome

Type Measure Description Time frame Safety issue
Primary Edema size measured by tape measure method the effect of preemptive intravenous ibuprofen on postoperative edema size 6 month
Secondary Maximum mouth opening measured with vernier caliper the effect of preemptive intravenous ibuprofen on postoperative trismus rate 6 month
See also
  Status Clinical Trial Phase
Completed NCT06003205 - Contributing Factors to Local Bioimpedance Spectroscopy N/A
Completed NCT02055872 - Furosemide and Albumin for Diuresis of Edema: A Pilot Randomized Controlled Trial Phase 3
Completed NCT01172522 - Topical Treatment of Under Eye Dark Circles and Swelling Phase 2
Completed NCT00602615 - Bioequivalency Study of Torsemide Tablets Under Fed Conditions N/A
Completed NCT00602303 - Bioequivalency Study of Torsemide Tablets Under Fasting Conditions N/A
Completed NCT00115726 - Trial Assessing the Effect of Preoperative Furosemide on Intraoperative Blood Pressure Phase 4
Completed NCT04595448 - Lymphatic Function in Patients With Secondary Tricuspid Valve Regurgitation
Recruiting NCT06014203 - Examination of Edema After Arthroscopic Shoulder Surgery
Completed NCT06010394 - Control of Edema in the Knee in Patients With Knee Osteoarthritis N/A
Recruiting NCT05310019 - Effect of Electroacupuncture in Patients Submitted Orthognathic Surgery and Mentoplasty N/A
Recruiting NCT03442166 - Effectiveness of Light-emitting Diode (LED) Photobiomodulation in the Extraction of Retained Lower Third Molars Phase 2
Completed NCT06220903 - The Effect of Complex Decongestive Therapy in Patients With Lymphedema N/A
Withdrawn NCT03603990 - Effect of Vitrectomy on the Evolution of Refractory Diabetic Macular Edema N/A
Recruiting NCT04927234 - Foot and Ankle Post-operative Oedema Management Using Geko™ N/A
Active, not recruiting NCT02876107 - Carboplatin and Paclitaxel With or Without Panitumumab in Treating Patients With Invasive Triple Negative Breast Cancer Phase 2
Recruiting NCT03704857 - Different Endodontic Treatment Techniques in Postoperative Symptoms, Apical Repair, Longevity of Rehabilitations, and Oral Health-related Quality of Life N/A
Recruiting NCT04606030 - LymphBridge: Surgical Evaluation for Breast Cancer-Associated Lymphedema (BioBridge) N/A
Completed NCT00732719 - Compression Device Safety Study on Edema Phase 2
Not yet recruiting NCT05534308 - Effect of Intraoperative Taping on the Control of Edema Resulting From Stripping N/A
Completed NCT04205253 - Tongue Depressor-related Ischemia-Reperfusion Injury in Tongue