Ebola Virus Disease Clinical Trial
Official title:
Piloting Clinical Bacteriology in the Ebola Virus Disease Care Response to Detect Intercurring Bloodstream Infections and Inform Appropriate Antibiotic Treatment
Despite access to experimental Ebola Virus Disease (EVD)-specific treatments, about 30% of
patients still die in the Ebola Treatment Centers (ETC) in DRC. There is limited study done
about the potential contribution of bacterial co-infections (in particular bloodstream
infections) to this adverse outcome, as blood cultures were so far rarely available in
epidemic areas. Findings from patients treated in Europe and the USA, and case discussions in
the field call for further investigation.
Building further on an ongoing microbiological surveillance project of ITM and INRB in DRC,
we are able to set up a research project which will pilot in a standardized manner clinical
bacteriology tools (bacterial blood cultures, biomarkers as CRP, procalcitonin and white
blood cell differential count, and clinical early warning scores) to study bacterial
bloodstream infection in EVD patients in the N-Kivu/Ituri outbreak.
This project will add evidence on 1) frequency, causative pathogen and antibiotic resistance
profiles of bacterial bloodstream infections, as well as 2) the predictive value of
biomarkers and early warning scores, in EVD patients at different timepoints during
hospitalization in an ETC in DRC. The results will inform appropriate antibiotic treatment in
an EVD setting and improve patient outcomes.
n/a
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