Clinical Trials Logo
  1. Home
  2. Early Alzheimer's Disease
  3. NCT04777396

A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE)

Early Alzheimer's Disease Clinical Trial

Official title:
A Randomised Double-blind Placebo-controlled Clinical Trial Investigating the Effect and Safety of Oral Semaglutide in Subjects With Early Alzheimer´s Disease (EVOKE)

Clinical Trial Summary

This study is done to find out whether the medicine, semaglutide, has a positive effect on early Alzheimer's disease. Participants will either get semaglutide or placebo (a "dummy" medicine which does not contain any study medicine) - which treatment participants get is decided by an equal chance. The study will last for up to 173 weeks (about 3 years and 4 months). Participants will have 17 clinic visits and 1 phone call with the study doctor. The study includes various tests and scans. At 10 of the clinic visits participants will have blood samples taken. Participants must have a study partner, who is willing to take part in the study. Women cannot take part if pregnant, breastfeeding or plan to become pregnant during the study period. A cerebrospinal fluid (CSF) sub-study will be performed as a part of the study. The sub-study will be performed on a selection of sites based on their experience with CSF sampling and willingness to participate in this sub-study. The endpoints related to this sub-study are exploratory only.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04777396
Study type Interventional
Source Novo Nordisk A/S
Contact
Status Active, not recruiting
Phase Phase 3
Start date May 18, 2021
Completion date October 23, 2026
View Details
See also
  Status Clinical Trial Phase
Active, not recruiting NCT04693520 - Biomarker Effects of ALZ-801 in APOE4 Carriers With Early Alzheimer's Disease Phase 2
Recruiting NCT05122598 - Development and Evaluation of Computerized Olfactory Training Program for Cognitive Decline in Early Alzheimer's Disease Phase 2
Active, not recruiting NCT04770220 - An Efficacy and Safety Study of ALZ-801 in APOE4/4 Early AD Subjects Phase 3
Active, not recruiting NCT03887455 - A Study to Confirm Safety and Efficacy of Lecanemab in Participants With Early Alzheimer's Disease Phase 3
Recruiting NCT05531656 - A Study to Evaluate the Safety and Efficacy of CT1812 in Early Alzheimer's Disease Phase 2
Recruiting NCT04599764 - High Definition Transcranial Direct Current Stimulation (HD-tDCS) for Early Alzheimer's Disease N/A
Completed NCT05161715 - Proof-of-concept, Open-label Study in Patients With Early Alzheimer's Disease Phase 2
Completed NCT02859207 - A Study to Evaluate the Pharmacokinetics of E2609 and Its Metabolites in Subjects With Mild and Moderate Hepatic Impairment Compared With Healthy Subjects Phase 1
Enrolling by invitation NCT06304883 - Long-term Extension of Phase 3 Study of ALZ- 801 in APOE4/4 Early AD Subjects Phase 3