Dyspnea Clinical Trial
— MORPHILDOfficial title:
Palliation of Dyspnea With Morphine in Patients With Interstitial Lung Disease
Verified date | April 2019 |
Source | University of Aarhus |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
36 patients with interstitial lung disease will be randomized to 1 weeks treatment with
morphine hydrochloride as oral linctus 5 mg, four times a day, and 5 mg as needed up to 4
times a day, or corresponding doses of placebo.
VAS score for dyspnea will be evaluated after 1 hour and 1 week at follow up. Other
questionnaires will also be evaluated (GAD-7, K-BUILD, Leicester score)
Status | Completed |
Enrollment | 36 |
Est. completion date | February 6, 2019 |
Est. primary completion date | February 6, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 110 Years |
Eligibility |
Inclusion Criteria: - A diagnosis of interstitial lung disease (IPF, NSIP, RA-ILS, Scl-ILS, MCTD-ILS, asbestous, drug induced ILD, unclassified ILD) - Dyspnea corresponding to Medial Research Councils (MRC) dyspnea score = 3 - Written consent - Age = 18 years - Competent - For fertile women: Negative pregnancy test - For fertile and sexually active participants: Use of safe anti-conceptionals Exclusion Criteria: - Ongoing infection - Decreased lung function to a degree which makes any form of respiratory depression life threatening - Treatment with morphine or morphine analogues - Allergy towards morphine hydrochloride |
Country | Name | City | State |
---|---|---|---|
Denmark | Aarhus University Hospital | Aarhus C |
Lead Sponsor | Collaborator |
---|---|
University of Aarhus | Skanderbog Apotek |
Denmark,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | VAS dyspnea score | 1 week | ||
Secondary | Oxygen saturation | Peripheral oxygen saturation will be measured after first dose of morphine and placebo as well as after 1 week follow up | 1 hour and 1 week | |
Secondary | K-bild questionnaire | questionnaire regarding interstitial lung specific life quality | 1 week | |
Secondary | GAD-7 questionnaire | VAlidatet score for anxiety and depression | 1 week | |
Secondary | 6 min walk test | 1 hour and 1 week | ||
Secondary | Leicester Score | cough related score | 1 week |
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT04688905 -
Diagnosing Heart Failure With Preserved Ejection Fraction in Patients With Unexplained Dyspnea (Diagnose-HFpEF)
|
||
Completed |
NCT03679312 -
The Effect of Inhaled Nitric Oxide on Dyspnea and Exercise Tolerance in COPD
|
Phase 1/Phase 2 | |
Recruiting |
NCT04868357 -
Hypnosis for the Management of Anxiety and Breathlessness During a Pulmonary Rehabilitation Program
|
N/A | |
Active, not recruiting |
NCT03604822 -
Music Therapy Protocol to Support Bulbar and Respiratory Functions in ALS
|
N/A | |
Completed |
NCT03626519 -
Effects of Menthol on Dyspnoea in COPD Patients
|
N/A | |
Completed |
NCT02638649 -
Prehospital Use of Ultrasound in Undifferentiated Shortness of Breath
|
||
Completed |
NCT02248831 -
Evaluation of Cardiopulmonary Diseases by Ultrasound
|
N/A | |
Completed |
NCT02538770 -
Rapid Viral Diagnostics in Adults to Reduce Antimicrobial Consumption and Duration of Hospitalization
|
N/A | |
Terminated |
NCT02269761 -
Chest Ultrasound of ER Patients With Cough or SOB
|
||
Recruiting |
NCT01655199 -
Sensitivity of the Step Test to Detect Improvement in Dyspnea Following Bronchodilation in Patients With Chronic Obstructive Pulmonary Disease
|
N/A | |
Active, not recruiting |
NCT01440764 -
Aerosol Inhalation Treatment for Dyspnea
|
Phase 1/Phase 2 | |
Completed |
NCT01577407 -
Non Opioid Treatment for Experimental Dyspnea
|
Phase 3 | |
Completed |
NCT01193998 -
Impact of Validated Diagnostic Prediction Model of Acute Heart Failure in the Emergency Department
|
N/A | |
Recruiting |
NCT04327882 -
Point-of-care Ultrasound Interest in Dyspneic Emergency Department Patients: an Observational Bicentric Study
|
||
Completed |
NCT05029986 -
Preventing Dyspnea During Speech in Older Speakers
|
N/A | |
Not yet recruiting |
NCT04181359 -
The Effect of Inhaled Nitric Oxide on Dyspnea and Exercise Tolerance in Interstitial Lung Disease.
|
Phase 1/Phase 2 | |
Recruiting |
NCT04615065 -
Acutelines: a Large Data-/Biobank of Acute and Emergency Medicine
|
||
Completed |
NCT04305639 -
The Reliability and Validity of Turkish Version of ''The Dyspnea-ALS-Scale (DALS-15)"
|
||
Completed |
NCT04370990 -
Automated Oxygen Administration -Rethinking Interventions Alleviating Dyspnea in Patients With COPD
|
N/A | |
Completed |
NCT04375917 -
Is Reduced Hypoxia Through a Robot Intervention, Associated With Sensory and Emotional Descriptions of Dyspnea, Anxiety, Depression, Symptom Burden and Anxiolytics
|
N/A |