Dysphagia Clinical Trial
Official title:
Quantitative MRI Evaluation of Esophageal Remodeling/Response to Treatment in Children and Adolescents With Eosinophilic Esophagitis Presenting With Dysphagia
To evaluate quantitative magnetic resonance imaging(MRI) as a potential non-invasive, radiation-free diagnostic tool for evaluating esophageal wall remodeling (thickness and stiffness) and response to treatment in children and adolescents with newly diagnosed eosinophilic esophagitis (EoE) presenting with dysphagia (difficulty swallowing) and food impaction.
Eosinophilic esophagitis(EoE) is a form of chronic inflammation affecting the esophagus
which often results in wall thickening and esophageal stiffening and is associated with
complications, such as esophageal tears and strictures (narrowings). Chronic dysphagia and
acute food impaction (swallowed food stuck in the esophagus) are common symptoms of EoE and
are associated with esophageal wall thickening and stiffness.
Current diagnostic techniques such as endoscopy with biopsy give only limited information
about changes in the esophageal wall in eosinophilic esophagitis(EoE). In routine clinical
practice, repeat endoscopic evaluation with biopsy is commonly performed about 3-6 months
after initial therapy for eosinophilic esophagitis(EoE). However, follow-up endoscopy with
biopsy has drawbacks as it is invasive, costly and typically requires deep sedation or
general anesthesia.
We propose to evaluate quantitative MRI as a potential non-invasive diagnostic option for
evaluating esophageal wall remodeling in patients with eosinophilic esophagitis(EoE).
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Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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