Is wGRS Associated With DD Recurrence?

Status Completed

Clinical Trial Summary

Rationale: Retrospectively reviewing the participants of the GODDAF database, revealed a significant association between the weighted genetic risk score and Dupuytren disease recurrence. However, a significant dose-response relation was not found. This might be caused by underestimating the recurrence rate, due to the retrospective nature of determining recurrence. Therefore, we want to do a follow-up measurement of the GODDAF participants, to see whether they suffered from recurrent disease. Objective: We aim to determine whether the wGRS is associated with recurrent DD. Study design: An observational study, in which the participants of the GODDAF study are followed up. Study population: Patients affected by Dupuytren disease, aged 18-96 years, who were previously included in another study on the genetic basis of Dupuytren disease. Intervention (if applicable): NA Main study parameters/endpoints: The main study parameter is the presence of recurrent Dupuytren disease.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02983162
Study type	Observational
Source	University Medical Center Groningen
Contact
Status	Completed
Phase
Start date	March 10, 2017
Completion date	August 1, 2018

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT03155854` - The Effects of Prophylactic Limited Palmar Fasciectomy on Surgical Outcomes and Scarring	N/A
Active, not recruiting	`NCT03192020` - Trial Comparing Treatment Strategies in Dupuytren's Contracture	Phase 4
Recruiting	`NCT05300893` - Effectiveness of Night Splinting After Percutaneous Needle Fasciotomy in Dupuytren's Contracture	N/A
Completed	`NCT02647619` - Dupuytren´s Disease Study. Primary Disease, MCP Joint, Xiapex, PNF	Phase 4
Recruiting	`NCT01184586` - Dupuytren's Disease and Extracorporeal Shockwave Therapy (DupuyShock-2010)	Phase 2
Recruiting	`NCT04122313` - Post-contracture Release Radiation for Dupuytren's Disease
Withdrawn	`NCT01776892` - Collagenase and Needle Aponeurotomy: Single Modality Versus Combination Treatment for Dupuytren's Disease	Phase 3
Completed	`NCT01923103` - Natural Disease Progress of Dupuytren Disease
Enrolling by invitation	`NCT03982719` - Comparing the Effectiveness of Two Post-fasciectomy Rehabilitation Protocols in Patients With Dupuytren's Disease	N/A
Not yet recruiting	`NCT04907812` - The Role of Tranexamic Acid in Reducing Post Operative Hand Edema After Hand and Wrist Surgery	Phase 4
Withdrawn	`NCT03031080` - BOND Study: the Benefit Of Night Splinting in Dupuytrens'	N/A
Completed	`NCT04874870` - Effectiveness of Splinting After Collagenase Injection	Phase 3
Active, not recruiting	`NCT03407820` - Different Sutures in Hand Surgery	N/A
Recruiting	`NCT03000114` - Collagenase Injection vs Percutaneous Needle Aponeurotomy for Dupuytren's Disease	Phase 4
Recruiting	`NCT05440240` - Percutaneous Needle Fasciotomy +/- Corticosteroid Injection for Dupuytren's Contracture	Phase 4
Completed	`NCT03331926` - Collagenase is a Common Treatment of MCP and PIP Joint Contractures in Dupuytrens Disease
Active, not recruiting	`NCT03741764` - Treatment of Dupuytren's Disease With Minimal Invasive Surgery and VIVOSORB® Resorbable Implant Device	N/A
Completed	`NCT01876498` - Registry of Patient With M. Dupuytren and Validation of the Brief MHQ	N/A
Completed	`NCT03868449` - Question Prompt List for Common Hand Conditions	N/A
Completed	`NCT03573765` - Epidemiology and Outcomes of Upper Limb Surgery: Analysis of Routine Data