Clinical Trials Logo
  1. Home
  2. Ductal Carcinoma In Situ
  3. NCT01023477

Study of the Efficacy of Chloroquine in the Treatment of Ductal Carcinoma in Situ (The PINC Trial)

Ductal Carcinoma In Situ Clinical Trial

Official title:
Preventing Invasive Breast Neoplasia With Chloroquine (PINC) Trial

Clinical Trial Summary

The purpose of this study is to test the hypothesis that chloroquine will reduce the ability of ductal carcinoma in situ (DCIS) to survive and spread. Participants will receive either chloroquine standard dose (500mg/week) or chloroquine low dose (250mg/week) for 1 month prior to surgical removal of the tumor.

Clinical Trial Description

The purpose of this study is to test the hypothesis that inhibiting the autophagy pathway in DCIS will reduce the capacity of DCIS to survive and invade. The study will examine the safety and effectiveness of neoadjuvant chloroquine administration for a one month period to patients with low, intermediate grade, or high grade DCIS. We will evaluate whether this treatment will reduce the capacity of DCIS neoplastic cells, existing within the duct, to survive, induce lesion regression, and kill the invasive DCIS progenitor cells. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01023477
Study type Interventional
Source Inova Health Care Services
Contact
Status Completed
Phase Phase 1/Phase 2
Start date December 2009
Completion date October 2016
View Details
See also
  Status Clinical Trial Phase
Active, not recruiting NCT02889458 - Hong Kong Breast Cancer Study
Completed NCT00757302 - Intraoperative Gamma Camera for Breast Cancer Surgery Phase 3
Active, not recruiting NCT03216421 - Intraoperative Radiation Therapy (IORT) in DCIS N/A
Completed NCT03775213 - Acceptability of Active Monitoring (AM) as a Treatment Option for Ductal Carcinoma in Situ (DCIS) N/A
Active, not recruiting NCT00605982 - Breast MRI as a Preoperative Tool for DCIS N/A
Enrolling by invitation NCT04365114 - Patient Outcomes From Second Film-readers and Test Threshold Relaxation in Breast Screening
Completed NCT04248179 - The Ultrasound-guided Multiple-injection Costotransverse Block for Mastectomy and Primary Reconstructive Surgery. Phase 4
Withdrawn NCT05032079 - Subzero and Scorpion Trial N/A
Recruiting NCT05218044 - Cryoablation as a Minimally Invasive Alternative to Surgery for Managing Ductal Carcinoma In Situ N/A
Active, not recruiting NCT01644669 - Safety and Efficacy Study of the Xoft® Axxent® eBx® IORT System® N/A
Recruiting NCT06133647 - Demographics, Characteristics and Outcomes of Male Breast Cancer Patients at Methodist Health System
Completed NCT01815476 - The Prone Breast Radiation Therapy Trial N/A
Not yet recruiting NCT06033092 - Low Dose TamOxifen and LifestylE Changes for bReast cANcer prevenTion Phase 2
Terminated NCT02137252 - Naltrexone RCT for Treatment-Emergent Fatigue in Patients Receiving Radiation Therapy for Breast Cancer Phase 2
Terminated NCT01060345 - A Pilot Study of Chemo-prevention of Green Tea in Women With Ductal Carcinoma in Situ Phase 2
Recruiting NCT00669747 - Study Of Intraductal Carboplatin In Women With Ductal Carcinoma In Situ (DCIS) Phase 2
Completed NCT00742222 - Electronic Xoft Intersociety Brachytherapy Trial: Electronic Brachytherapy (EBT) For Treatment of Early Stage Breast Cancer Phase 4
Active, not recruiting NCT02909426 - The Mammography and Ultrasonography STudy for Breast Cancer Screening Effectiveness
Recruiting NCT02928978 - Ruxolitinib for Premalignant Breast Disease Phase 2
Completed NCT03375892 - The Use of Deep Inspiration Breath Hold and Prone Irradiation to Decrease Cardiac Radiation Exposure N/A