Dry Eye Clinical Trial - Azithromycin for Meibomian Gland Disease

Status Recruiting

Clinical Trial Summary

This study aims to elucidate the effectiveness of oral azithromycin in treating symptomatic dry eye syndrome secondary to Meibomian gland dysfunction.

Clinical Trial Description

This is a randomized, placebo-controlled, double masked trial of the effectiveness of oral azithromycin in treating symptomatic dry eye syndrome secondary to Meibomian gland dysfunction. Dry eye syndrome (DES) is a persistent feeling of ocular discomfort that encompasses dryness, irritation, foreign body sensation and burning. In the United States, it is the most common non-refractive cause of visits to eye care providers, and has been shown to have a significant impact on quality of life of patients who suffer from this condition. most common cause of DES is Meibomian gland disease (MGD). In the vast majority of cases, MGD is not binding, but rather causes persistant ocular discomfort. Oral antibiotics, particularly the tetracyclines and macrolides, are frequently prescribed for the treatment of MGD. There is little good-quality evidence to support this practice. This study is designed to evaluate the effectiveness of oral azithromycin on patient-reported dry eye symptoms. Concomitantly, we will also study the composition of the ocular surface microbiome in MGD, and its response for oral antibiotics. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03953118
Study type	Interventional
Source	University of California, San Francisco
Contact	Khashayar Nattagh, BA
Phone	19499107667
Email	khash.nattagh@ucsf.edu
Status	Recruiting
Phase	Phase 4
Start date	September 1, 2018
Completion date	December 1, 2023

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