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Effects of Xiidra on Closed Eye Tear Film Leukocytes in Dry Eye Disease

Dry Eye Clinical Trial

Official title:
Effects of Xiidra on Closed Eye Tear Film Leukocytes in Dry Eye Disease

Clinical Trial Summary

Every night during sleep, there is an accumulation of white blood cells in the closed eye. The closed eye white blood cells are predominantly neutrophils, but there is a small population (3%) of T cells. The effects of these closed eye white blood cells on dry eye disease pathogenesis have yet to be fully elucidated, but preliminary evidence suggests that closed eye neutrophils may have an associated hyperactivity and increased degranulation in dry eye disease that could contribute to epithelial instability. As an anti-T cell therapy, Xiidra offers an opportunity to better understand how the closed eye white blood cells are recruited and activated. This study also seeks to verify the proposed mechanism of action.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03408015
Study type Interventional
Source University of Alabama at Birmingham
Contact
Status Withdrawn
Phase Phase 4
Start date January 2019
Completion date January 30, 2019
View Details
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