Wumeiwan Jiawei Fang Use in Patients With Blepharospasm

Status Recruiting

Clinical Trial Summary

To evaluate the efficacy and safety of Jing Fang Wu Mei Wan Jiawei Fang in the treatment of idiopathic blepharospasm using a clinical randomized controlled trial method.

Clinical Trial Description

Idiopathic blepharospasm is an idiopathic dysfunction characterized by involuntary spasms of the eyelids bilaterally that interfere with visual function and cause ocular discomfort. The incidence has increased each year in recent years, and the disease may present with persistent eye closure or even functional blindness in advanced stages. In some patients, the disease may be associated with submandibular dystonia, known as Meige's syndrome. Currently, the disease is treated symptomatically. Such as oral.These treatments not only have large side effects, but also make it difficult to relieve the patient of multiple lesions in the eyes, face and tongue. Chinese medicine has unique advantages in treating this disease, highlighting the overall diagnosis and solving different parts of the disease in an integrated manner. Wu Mei Wan is a traditional Chinese medicine prescription, and our team has been using Wu Mei Wan Jia Wei Fang for the treatment of Meige syndrome since 2009 under the leadership of Gao Jiansheng, a famous Chinese medicine teacher in the capital, and found significant therapeutic effects in preliminary clinical observation, but there is a lack of large sample of randomized controlled clinical studies. In this study, we propose to systematically observe the efficacy of traditional Chinese medicine in the treatment of idiopathic blepharospasm by using the traditional sutra formula for idiopathic blepharospasm as a test group and local botulinum toxin A injection as a control group, and to scientifically evaluate the efficacy of the Wu Mei Wan Jia Wei Fang in the treatment of idiopathic blepharospasm.The results were evaluated in order to provide new treatment options for the clinical management of idiopathic blepharospasm (including Meige syndrome) and to benefit more patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05618470
Study type	Interventional
Source	China Academy of Chinese Medical Sciences
Contact	wei yang
Phone	18600484803
Email	506910548@qq.com
Status	Recruiting
Phase	Phase 2/Phase 3
Start date	January 12, 2018
Completion date	September 30, 2024

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT04425551` - Effect of Micropulse Laser on Dry Eye Disease Due to Meibomian Gland Dysfunction	N/A
Not yet recruiting	`NCT06379685` - Study to Evaluate the Safety and Tolerability of PRO-190 Ophthalmic Solution Compared to Systane Ultra® on the Ocular Surface.	Phase 1
Recruiting	`NCT04701086` - 3 Month Study of Cationorm Pro Versus Vismed in Adults With Dry Eye Disease Related to Keratitis or Keratoconjunctivitis	N/A
Active, not recruiting	`NCT03697876` - Safety and Tolerability of the Ophthalmic Gel PRO-165 Versus Artelac® Nightime Gel	Phase 1
Terminated	`NCT02815293` - Topical Ophthalmic AGN-195263 for the Treatment of Evaporative Dry Eye	Phase 3
Completed	`NCT02910713` - Evaluation of Dry Eye Symptoms in CAE With Application of Intranasal Neurostimulation	N/A
Completed	`NCT04104997` - A Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetic Characteristics of GLH8NDE After Single and Mutiple Ocular Administrations in Healthy Korean and Caucasian Volunteers	Phase 1
Recruiting	`NCT02595606` - 0.3% Sodium Hyaluronate in the Treatment of Dry Eye of Diabetic Patients	Phase 4
Completed	`NCT01711424` - An Observational Study of OPTIVE PLUS® for the Treatment of Dry Eye Disease	N/A
Completed	`NCT01202747` - Evaluation of Screening Methods for Treatment of Meibomian Gland Dysfunction	Phase 2/Phase 3
Completed	`NCT01015209` - Safety and Tolerability of Chitosan-N-acetylcysteine Eye Drops in Healthy Young Volunteers	Phase 1
Completed	`NCT00969280` - Acupuncture for Dry Eye Syndrome	Phase 3
Completed	`NCT00739713` - Effects of Sea Buckthorn Oil on Dry Eye	N/A
Completed	`NCT00756678` - Efficacy and Acceptability of Two Lubricant Eye Drops	Phase 4
Completed	`NCT01496482` - Comparison of Evaporimetry With the Established Methods of Tear Film Measurement	N/A
Completed	`NCT00349440` - Efficacy of Cyclosporine for the Prevention and Treatment of Dry Eye Symptoms Following LASIK or Photorefractive Keratectomy	Phase 4
Completed	`NCT00370747` - Efficacy and Safety Study for Ecabet Ophthalmic Solution for Treating Dry Eye Syndrome	Phase 2
Completed	`NCT05162261` - to Evaluate the Effectiveness and Safety of the Tixel® , VS LipiFlow® in the Treatment of Meibomian Gland Dysfunction	N/A
Completed	`NCT02871440` - A Two Comparator, Controlled Phase 3 Study in Patients With and Without Evaporative Dry Eye	Phase 3
Completed	`NCT05042960` - Computer Screen Properties Study	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.