Effect of ADDE on Tear Interferometry

Status Completed

Clinical Trial Summary

Importance: Lipid layer thickness (LLT) reflects the lipid components of tear film, but is affected by the mucocutaneous components. This study investigated the therapeutic effect of the treatments for aqueous-deficient dry eye (ADDE) on LLT. Objective: To investigate the effect of ADDE and its treatments on LLT measurements by tear interferometry. Design, Setting, and Participants: This prospective comparative interventional study included 152 eyes from 152 patients with ADDE. Interventions: Participants were classified into four groups: control group (Group 1), 3% diquafosol group (Group 2), punctal plug insertion group (Group 3), and combined treatment group (Group 4). Main Outcomes and Measures: Average LLT (LLTave) was measured using a LipiView® II tear interferometer at baseline and one month after treatments.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05456061
Study type	Interventional
Source	Yonsei University
Contact
Status	Completed
Phase	N/A
Start date	August 1, 2018
Completion date	January 31, 2022

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT04425551` - Effect of Micropulse Laser on Dry Eye Disease Due to Meibomian Gland Dysfunction	N/A
Not yet recruiting	`NCT06379685` - Study to Evaluate the Safety and Tolerability of PRO-190 Ophthalmic Solution Compared to Systane Ultra® on the Ocular Surface.	Phase 1
Recruiting	`NCT04701086` - 3 Month Study of Cationorm Pro Versus Vismed in Adults With Dry Eye Disease Related to Keratitis or Keratoconjunctivitis	N/A
Active, not recruiting	`NCT03697876` - Safety and Tolerability of the Ophthalmic Gel PRO-165 Versus Artelac® Nightime Gel	Phase 1
Completed	`NCT02910713` - Evaluation of Dry Eye Symptoms in CAE With Application of Intranasal Neurostimulation	N/A
Terminated	`NCT02815293` - Topical Ophthalmic AGN-195263 for the Treatment of Evaporative Dry Eye	Phase 3
Completed	`NCT04104997` - A Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetic Characteristics of GLH8NDE After Single and Mutiple Ocular Administrations in Healthy Korean and Caucasian Volunteers	Phase 1
Recruiting	`NCT02595606` - 0.3% Sodium Hyaluronate in the Treatment of Dry Eye of Diabetic Patients	Phase 4
Completed	`NCT01711424` - An Observational Study of OPTIVE PLUS® for the Treatment of Dry Eye Disease	N/A
Completed	`NCT01202747` - Evaluation of Screening Methods for Treatment of Meibomian Gland Dysfunction	Phase 2/Phase 3
Completed	`NCT01015209` - Safety and Tolerability of Chitosan-N-acetylcysteine Eye Drops in Healthy Young Volunteers	Phase 1
Completed	`NCT00969280` - Acupuncture for Dry Eye Syndrome	Phase 3
Completed	`NCT01496482` - Comparison of Evaporimetry With the Established Methods of Tear Film Measurement	N/A
Completed	`NCT00756678` - Efficacy and Acceptability of Two Lubricant Eye Drops	Phase 4
Completed	`NCT00739713` - Effects of Sea Buckthorn Oil on Dry Eye	N/A
Completed	`NCT00370747` - Efficacy and Safety Study for Ecabet Ophthalmic Solution for Treating Dry Eye Syndrome	Phase 2
Completed	`NCT00349440` - Efficacy of Cyclosporine for the Prevention and Treatment of Dry Eye Symptoms Following LASIK or Photorefractive Keratectomy	Phase 4
Completed	`NCT05162261` - to Evaluate the Effectiveness and Safety of the Tixel® , VS LipiFlow® in the Treatment of Meibomian Gland Dysfunction	N/A
Completed	`NCT02871440` - A Two Comparator, Controlled Phase 3 Study in Patients With and Without Evaporative Dry Eye	Phase 3
Completed	`NCT05042960` - Computer Screen Properties Study	N/A