Drug Allergy Clinical Trial
Official title:
Multiple Drug Hypersensitivity Syndrome in a Large Database
Background: Multiple drug hypersensitivity syndrome (MDH) is defined as confirmed drug
hypersensitivity reactions (DHRs) to at least 2 chemically and pharmacologically unrelated
drugs. Reports of MDH are scarce and poorly specified and studies which diagnose MDH on the
basis of positive allergy tests are lacking.
Objective: To evaluate retrospectively the frequency and characteristics of MDH patients in a
large database.
Methods: All the patients who consulted and were tested in our Allergy Unit between September
1996 and February 2018, with confirmed MDH will be included. Clinical history and allergy
work-up results will be extracted from our Drug Allergy and Hypersensitivity Database (DAHD).
The frequency of MDH will be calculated, MDH patients will be described, the most frequent
associations of DHRs will be identified and analysed.
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