Drug Abuse Among Elective Surgeries: an Observational Study.

Drug Abuse Clinical Trial

Official title:

Incidence of Drug Abuse at the Cairo University Teaching Hospital Among Patients Who Underwent Elective Surgeries

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05123521
• Other study ID #: amera master
• Status: Completed
• Start date: August 1, 2018
• Est. completion date: February 28, 2019

Study information

• Verified date: November 2021
• Source: Cairo University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Drug abusers and addicts form a challenge to the anesthetist because of the added potential risks involved in the administration of anesthesia to this subset of patients, including potential unforeseen drug-drug interactions. In this study, we aimed at screening all patients scheduled for elective orthopedic or general surgeries at the Cairo University Teaching Hospital during a set period of time for the most commonly abused drugs in Egypt.

Description:

All patients included in the study consented to take part in this study. Each patient was asked to answer a questionnaire and submit a urine sample in order to be screened for the most commonly abused drugs in Egypt (hashish, tramadol, benzodiazepine, and morphine). Patients were then followed up both intra and post-operatively. Values of patient vital signs, Richmond Agitation-Sedation Scale (RASS) scores as well as clinical recovery scores (CRS) were all diligently recorded and analyzed.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 500
• Est. completion date: February 28, 2019
• Est. primary completion date: January 28, 2019
• Gender: All
• Age group: 15 Years to 60 Years

Eligibility

Inclusion Criteria:

• male or female patients classified as American Society of Anaesthesiology (ASA) I or II patients

• patients between 15 and 60 years of age

• patients scheduled for elective surgery.

Exclusion Criteria:

• emergency surgery

• those with disturbed conscious levels

• history of psychological illness

• who refused to give consent

Related Conditions & MeSH terms

• Drug Abuse
• Substance-Related Disorders

Intervention

Diagnostic Test:
• urine analysis
Urine was then tested for evidence of substance abuse using the multi-drug screen panel dip steak ABONtm (Abon Biopharm (Hangzhou) CO., Ltd) which is a lateral flow chromatographic immunoassay . It allowed for qualitative detection of multiple drugs in a single run. This kit was chosen for its ability to detect the most commonly abused substances in Egypt, namely: opioids, benzodiazepines, hashish, and tramadol. A single coloured line at region C for of a specific drug indicated a positive result, whilst two coloured lines at both regions C and T indicated a negative result. The absence of coloured lines was an indication of the invalidity of the particular kit, and the kit was discarded.

Locations

Country	Name	City	State
Egypt	Cairo University	Cairo	Giza

Sponsors (1)

Lead Sponsor	Collaborator
Cairo University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	urine analysis	multi-drug screen panel dip steak (Abon Biopharm (Hangzhou) , Ltd)	THREE MONTHS