| Eligibility |
Inclusion Criteria:
1. Male or female subjects with DS with a cytogenetic diagnosis being either trisomy 21
or complete unbalanced translocation of the chromosome 21.
2. Age = 40 and = 50 years at screening.
3. Elevated brain Aß as evidenced by composite SUVR = 1.25 on florbetaben PET scan
assessed by central reading.
4. Subjects, their legal representatives (if applicable) and/or their study partners in
the opinion of the investigator, are able to understand and to provide written
informed consent before starting any study-related activities.
5. In the opinion of the investigator, subjects, their legal representatives (if
applicable) and/or their study partners are able to fully participate in the study, be
sufficiently proficient in the official languages(s) of the country they are living
in, and be capable of reliably completing study assessments.
6. Mild to moderate intellectual disability as per Diagnostic and Statistical Manual of
Mental Disorders (DSM-5) classification.
7. Subjects must have a study partner who has direct and regular contact with the subject
and who is able to provide reliable answers to questions related to the subject,
according to the study investigator.
8. Subjects in preclinical stage of AD or with mild cognitive impairment due to AD.
Exclusion Criteria:
1. Clinical diagnosis of AD dementia in DS as per International Classification of
Diseases 10 (ICD-10).
2. DSQIID > 20.
3. Intelligence quotient score = 40 (KBIT-2).
4. Diagnosis of autism spectrum disorder or any other unstable/uncontrolled psychiatric
or neurologic illness other than DS.
5. Any unstable and/or clinically significant medical condition likely to hamper the
evaluation of safety and/or efficacy of the study vaccine (eg, severe and untreated
obstructive sleep apnea, clinically significant reduction in serum B12 or folate
levels, clinically significant abnormalities of thyroid function, stroke or other
cerebrovascular conditions), as per investigator's judgement.
6. Subjects considered to be unable to complete any study exams and assessments (eg,
because of significant hearing or visual impairments or other disabilities), according
to the investigator, and potentially affecting study compliance.
7. DSM-5 criteria for drug or alcohol abuse or dependence currently met within the past 5
years.
8. History or presence of uncontrolled seizures. If history of seizures, they must be
well controlled with no occurrence of seizures in the 2 years before study screening.
The use of antiepileptic medications is permitted.
9. History of meningitis or meningoencephalitis.
10. History of moderate or severe traumatic brain injury.
11. History of cancer within the past 5 years other than treated squamous cell carcinoma,
basal cell carcinoma and melanoma in-situ, in-situ prostate cancer, or in-situ breast
cancer which have been fully removed and are considered cured.
12. History of inflammatory neurological disorders.
13. History of autoimmune disease with potential for central nervous system involvement.
14. Severe infections or a major surgical operation within 3 months before screening.
15. History of chronic or recurrent infections judged to be clinically significant by the
investigator and would potentially hamper the evaluation of efficacy and safety
assessments.
16. History or presence of immunological or inflammatory conditions judged to be
clinically significant by the investigator.
17. History of severe allergic reaction (eg, anaphylaxis) including, but not limited to,
severe allergic reaction to previous vaccines, foods, and/or medications.
18. Clinically significant abnormal vital signs including sustained sitting blood pressure
greater than 160/90 mm Hg.
19. Subjects who have donated blood or blood products in the 30 days before screening or
who plan to donate blood while participating in the study or within 4 weeks after
completion of the study.
20. Subjects with diabetes mellitus with hemoglobin A1c (HbA1c) levels of = 8.0%.
21. Any contraindication for lumbar puncture for those subjects consenting to the optional
lumbar puncture.
22. MRI scan at screening showing a single area of cerebral vasogenic edema, superficial
siderosis, or evidence of a previous macrohemorrhage or showing more than 4 cerebral
microhemorrhages (regardless of their anatomical location or diagnostic
characterization as "possible" or "definite"). Evidence of space-occupying lesions
other than benign meningioma of less than 1 cm diameter, more than 2 lacunar infarcts,
or 1 single infarct larger than 1 cm in diameter. Screening MRI scan showing
structural evidence of alternative pathology not consistent with AD and is considered
to be at the origin of subject's symptoms.
23. In the opinion of the site investigator, deviations from normal values for hematologic
parameters, liver function tests, and other biochemical measures, judged to be
clinically significant by the investigator.
24. Subjects with a positive Human Immunodeficiency Virus (HIV) test at screening.
25. Subjects with clinical or laboratory evidence of active Hepatitis B or C at screening.
26. Subjects with positive syphilis serology consistent with active syphilis at screening.
27. Clinically significant arrhythmias or other abnormalities on ECG at screening (minor
abnormalities documented as clinically insignificant by the investigator are allowed).
28. Any vaccine received within the 2 weeks before screening, including influenza vaccine.
29. Subjects with treated hypothyroidism not on a stable dose of replacement medication
for at least 3 months before screening and having clinically significant abnormal
serum T4 and/or thyroid-stimulating hormone at screening.
30. Subjects who have been receiving any experimental drug with a washout less than 30
days or less than 5 half-lives of the drug, whichever is longer.
31. Subjects being treated with any anticoagulants or antiplatelet drugs, except aspirin
at doses of 100 mg daily or lower.
32. Use of antidepressants (other than selective serotonin reuptake
inhibitors/serotonin-norepinephrine reuptake inhibitors at stable dose);
antipsychotics (typical or atypical); ?-aminobutyric acid agonists (eg, gabapentin);
or stimulants (eg, methylphenidate, modafinil). Stable doses of atypical
antipsychotics or benzodiazepines are only allowed if this is not considered to
influence the assessments, the safety, and the efficacy of the study vaccine according
to the site investigator and the site monitor.
33. Current use of anticholinergic agents for bladder dysfunction (eg, oxybutynin,
tolterodine, darifenacin, solifenacin, trospium, or fesoterodine) or subjects who have
received such treatments within a time period corresponding to 5 half-lives of the
respective agent before screening.
34. Chronic use of opioid analgesics. However, limited treatment duration for acute
conditions until 24 hours before cognitive assessment is allowed.
35. Current use of antihistaminic agents, especially of first generation. Limited use of
second-generation antihistaminics for acute conditions is allowed if not anticipated
to influence the cognitive assessments, according to the investigator.
36. Current use of immunosuppressant or immunomodulating drugs or their use within the 6
months before study screening. Current use of oral steroids or their use within the 3
months before study screening.
37. Previous treatment with ACI-24 or any other passive or active immunotherapy against AD
and/or for neurological disorders (passive immunization within the 6 months before
screening, active immunization at any time point) unless there is firm evidence that
the subject was treated with placebo only, and the placebo formulation is not expected
to induce any specific immune response.
38. Use of acetylcholinesterase inhibitors or use of glutamatergic drugs (eg, memantine,
topiramate, lamotrigine) if not on stable dose for at least 2 months before screening.
39. Concomitant participation in any other clinical study using an investigational drug.
40. Female subjects who are pregnant as confirmed by serum testing at screening or who are
planning to become pregnant or lactating.
41. Female or male subjects not using a reliable method of contraception during the
treatment period and for 26 weeks (6 months) after the last administration of study
vaccine.
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