DLBCL Clinical Trial
Official title:
Prospective, Multicenter, Randomized ,Open-labeled, Phase III Study Comparing High-dose Intravenous Methotrexate Versus Intrathecal Methotrexate for the Prophylaxis of Central Nervous System Relapse in Diffuse Large B Cell Lymphoma
The outcome of patients with central nervous system (CNS) relapse in DLBCL is poor, with
median survival times of 2-5 months. This fatal prognosis necessitates CNS prevention in a
subgroup of patients with a high risk of CNS relapse.
Intrathecal methotrexate (ITMTX) has traditionally been used, although its efficacy for CNS
prophylaxis is contradictory. High-dose intravenous methotrexate (IVMTX) has been suggested
as an alternative approach. Considering the lack of evidence supporting the role of ITMTX,
the investigators propose to compare the efficacy of ITMTX and IVMTX for prophylaxis of CNS
relapse in a subgroup of patients with DLBCL at a high risk for CNS relapse.
n/a
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