Does Vitamin C Reduce Finger Stiffness After Distal Radius Fractures?

Status Completed

Clinical Trial Summary

The reported prevalence of disproportionate pain and disability among patients recovering from a fracture of the distal radius varies widely. Literature reports numbers between 1% and 37%, perhaps in part because it is poorly defined, known by so many different names, subjective, and unverifiable.

The investigators are interested in the effect of vitamin C after distal radius fractures on objective measurement of finger motion, patient reported outcome measures, and pain intensity, instead of the previously used, subjective and imprecise criteria for complex regional pain syndrome.

Patients presenting to the Hand and Orthopaedic Trauma Services of MGH with a distal radius fracture will be asked to participate in this clinical trial. Patient will be randomly assigned to take either placebo or vitamin C 500 mg until full finger motion is attained as regarded by the treating physician at follow-up or for 6 weeks.

The investigators hypothesize no difference in finger stiffness at 6 weeks measured by distance to palmar crease of the index through little finger between patients taking vitamin C or placebo after a distal radius fracture. Additionally, the investigators assess finger stiffness by range of motion and stiffness of the thumb, and difference in PROMIS upper extremity function and pain score both measured at six months.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02216812
Study type	Interventional
Source	Massachusetts General Hospital
Contact
Status	Completed
Phase	N/A
Start date	August 2014
Completion date	December 22, 2017

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05736068` - Is Casting of Displaced Pediatric Distal Forearm Fractures Non-inferior to Reduction in General Anesthesia?	N/A
Completed	`NCT04554472` - Usefulness of Intraoperative Ultrasound in a Volar Plate Distal Radius Fixation
Completed	`NCT03613922` - Effects of Early Manual Therapy on Functional Outcomes After Volar Plating of Distal Radius Fractures	N/A
Completed	`NCT01823692` - Evaluating Validity of Ultrasonography in Determining Distal Radius Fracture Reduction	Phase 2
Completed	`NCT02286661` - Short-Arm Casting Effective in Type A2 Fractures in the Distal Radius	N/A
Completed	`NCT01062997` - Volar Locked Plating Versus Bridging External Fixation	N/A
Not yet recruiting	`NCT04100317` - Spanning Bridged Plate in Comminuted Distal Radius Fractures
Recruiting	`NCT04976335` - Quantitative and Clinical Assessment of Flexor Tendon Gliding Following Application of a Bioresorbable Hydrogel: A Prospective, Randomized Study in Patients Undergoing Distal Radius Fracture Repair	N/A
Completed	`NCT03635060` - Distraction Osteogenesis for Distal Radius Fractures vs. Volar Plating	N/A
Not yet recruiting	`NCT05095415` - Occupational Therapy Pre-operative Education in the Orthopedic Hand Setting	N/A
Terminated	`NCT02744352` - Single Shot vs Catheter Infraclavicular Brachial Plexus Block After Distal Radius Fracture Repair	N/A
Completed	`NCT01778673` - Cortical Comminution and Intra-articular Involvement in Distal Radius Fractures Can Predict Radiological Outcome. A Prospective Multicenter Study	N/A
Completed	`NCT05558306` - Radiological vs Clinical Outcome in DRF	N/A
Active, not recruiting	`NCT03349216` - Bier's Block Versus Systemic Analgesia	Phase 2
Completed	`NCT04357470` - Manual Dexterity in Ulnar Styloid Fracture Patients	N/A
Completed	`NCT05360836` - The Effect of Motor Imagery in Patients With Radius Distal End Fracture	N/A
Recruiting	`NCT02957240` - Graded Motor Imagery for Women at Risk for Developing Type I CRPS Following Closed Treatment of Distal Radius Fractures	N/A
Completed	`NCT03240471` - Cast OFF Trial: One Versus Four-five Weeks of Plaster Cast Immobilization	N/A
Terminated	`NCT04089709` - Well-arm Exercise in Distal Radius Fractures	N/A
Completed	`NCT05623865` - The Effect of Kinesio Taping on Edema Control and Wrist Functions in Conservatively Followed Distal Radius Fractures.	N/A