Disorder of Consciousness Clinical Trial
Official title:
Effects of Repetitive Transcranial Magnetic Stimulation on the Disorders of Consciousness
Transcranial magnetic stimulation involves the use of alternating magnetic fields to stimulate neurons in the brain.To date, several studies have focused on the use of TMS in patients with impaired consciousness.However,its therapeutic effects have been variously documented.So,in this study ,investigators explore the effects of rTMS with cross-over design.
Background:Repetitive transcranial magnetic stimulation (rTMS) was supposed as an
experimental approach to disorders of consciousness treatment. Its therapeutic effects have
been variously documented.
Objective: The study aimed to investigate the reactivity of electroencephalography (EEG) and
the clinical response of patients with disorders of consciousness and explore the
neuromodulatory effects of high-frequency rTMS in DOC.
Method:In this randomised,sham-controlled study,real or sham 20 Hz rTMS were applied to the
left primary motor cortex (M1) of participants with disorders of consciousness for 5
consecutive days . Evaluations were blindly performed at baseline, immediately after the end
of the 5-days treatment and 1 week later with the JFK Coma Recovery Scale-Revised (CRS-R)
scale and EEG.
Hypothesis:Real rTMS can be an effective awakening method.
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