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Disorder of Consciousness clinical trials

View clinical trials related to Disorder of Consciousness.

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NCT ID: NCT05954650 Completed - Clinical trials for Disorder of Consciousness

Clinical Validity of the Minimally Conscious State "Plus" and "Minus"

Start date: September 30, 2004
Phase:
Study type: Observational

The goal of this observational retrospective study is to investigate and compare the clinical evolution of a sample of patients with the diagnosis of MCS+ versus MCS- according to the CRS-R. The main questions it aims to answer are the presence of differences in the likelihood of emergence from the MCS (EMCS) between these two groups and in the progress of disability and functional independence after the EMCS.

NCT ID: NCT05819177 Completed - Clinical trials for Disorder of Consciousness

Information of the Coma Recovery Scale-Revised for Neurobehavioral State and Recovery of Consciousness Prediction

CRS-R_Info
Start date: February 1, 2004
Phase:
Study type: Observational

Background: The Coma Recovery Scale-Revised (CRS-R) is the most recommended instrument to examine the neurobehavioral condition of individuals with disorders of consciousness (DOCs). Different studies have investigated the prognostic value of the information provided by the conventional administration of the scale, while other measures derived from the scale have been proposed to improve the prognosis of DOCs. However, the heterogeneity of the data used in the different studies prevents a reliable comparison of the identified predictors and measures. Objectives: This study investigates which information derived from the CRS-R provides the most reliable prediction of both the neurobehavioral state and recovery of consciousness at the discharge of a long-term neurorehabilitation program. Methods: The clinical records of 171 individuals with DOCs admitted to an inpatient neurorehabilitation program for a minimum of 3 months were used to implement machine learning classifiers that were trained to predict the neurobehavioral state and recovery of consciousness at discharge.

NCT ID: NCT05536921 Completed - Clinical trials for Traumatic Brain Injury

Eye Tracking Technology in the Diagnosis of Neurological Patients

Start date: May 1, 2022
Phase:
Study type: Observational

Demonstrating that diagnostics of the state of consciousness and cognitive functions of patients with consciousness disorders performed using C-Eye X (based on eye-tracking technology) allows a more objective assessment of state of patients who were wrongly diagnosed based on popular methods using in a clinical practice (like behavioural scales on paper forms).

NCT ID: NCT05308186 Completed - Clinical trials for Disorder of Consciousness

Effectiveness of Sensory Stimulation on Attenuating Pain and Stress Among Patients With Disorders of Consciousness

Start date: April 10, 2022
Phase: N/A
Study type: Interventional

The aim of the presented study is to examine the effectiveness of sensory stimulation in reducing pain and stress of patients diagnosed with Disorder of consciousness.

NCT ID: NCT04921683 Completed - Clinical trials for Traumatic Brain Injury

The Use of LIFUP in Chronic Disorders of Consciousness

Start date: June 21, 2021
Phase: N/A
Study type: Interventional

When patients survive a severe brain injury but fail to fully recover, they often enter a Disorder of Consciousness (DoC) --that is, a set of related conditions of decreased awareness and arousal including the Vegetative State (VS) and the Minimally Conscious State (MCS). When these conditions become chronic, there are no approved treatments to help bolster any further recovery. In prior work, we have shown the clinical feasibility and potential of Low Intensity Focused Ultrasound Pulsation (LIFUP) as a remarkably safe form of non-invasive brain stimulation in these conditions.

NCT ID: NCT04614792 Completed - Clinical trials for Disorder of Consciousness

Excitatory Prefrontal Weak Current Stimulation in Vegetative Patients

VEG-TDCS
Start date: April 30, 2014
Phase: N/A
Study type: Interventional

In response to "conscious" EEG findings related to detectable cognitive function that reliably denote awareness in vegetative state patients, in the current study, we will assess the covert conscious EEG activity (as well as standard clinical overt measures) and neuroplasctic propensity (i.e., changes in EEG spectral power synchronization values following tDCS intervention) in vegetative-state patients receiving repetitive transcranial direct current stimulation (tDCS) treatment over frontal motor areas for a period of two weeks. In support of this approach, a recent tDCS study with vegetative and minimally conscious patients implied that a twenty minutes anodal stimulation (i.e., excitatory stimulation) to the left dorsolateral prefrontal cortex (DLPFC) significantly increased CRS-R scores versus sham (placebo: non-active stimulation) stimulation condition. It was noted that this tDCS effect was more pronounced in minimally conscious state patients versus vegetative state patients excluding effects of chronicity or etiology. Thus, the investigators in this study suggested that tDCS could be effective in improving cognitive recovery in severely brain-injured patients. However, their findings would benefit neural activation correlates that could support their conclusion regarding the effectiveness of this type of non-invasive intervention in promoting neurocognitive recovery. Most importantly, tDCS is safe for use in humans, has no adverse effects, is considered the most non-invasive transcranial stimulation method because it uses extremely weak currents (0.5 to 2 mA), and, is known to only temporarily shift the neuron's membrane potential towards excitation/inhibition. In regard to the method's potential to induce functional recovery in vegetative state patients, recent clinical studies indicate that tDCS could counteract the negative effects of brain damage by influencing neurophysiological mechanisms, and is likely to contribute to the "formation of functionally meaningful connections and the maintenance of existing pathways" .

NCT ID: NCT04530968 Completed - Clinical trials for Disorder of Consciousness

Metabolic Abnormalities and Intestinal Microecology in Patients With Chronic Disorders of Consciousness

Start date: March 13, 2018
Phase:
Study type: Observational

Following severe traumatic brain injury, patients may remain unconscious for many years. It is the intestinal microbiome and metabolomics analysis comparing differentially intestinal microflora and metabolites between patients with chronic disorder of consciousness and controls so far. The investigators have mature data analysis technology. The obtained results provide new insight into understanding the molecular mechanisms underlying the chronic disorder of consciousness

NCT ID: NCT04471753 Completed - Clinical trials for Disorder of Consciousness

Target Behaviours to Identify Minimally Conscious State Patients

Start date: August 1, 2017
Phase:
Study type: Observational

To analyse the frequency of the consciousness behaviour response for patients with minimally conscious state of Coma Recovery Scale-Revised items, as well as the necessary items for obtaining higher accuracy. In addition, providing target behaviours for Coma Recovery Scale-Revised assessment of minimally conscious state diagnosis and evidence for the simplification of Coma Recovery Scale-Revised in the future.

NCT ID: NCT04164680 Completed - Clinical trials for Disorder of Consciousness

Simultaneously PET/MRI in Prolonged DOC Patients

Start date: January 1, 2018
Phase:
Study type: Observational

Recently introduced hybrid PET/MR scanners provide the opportunity to measure simultaneously, and in direct spatial correspondence, both metabolic demand and functional activity of the brain, hence capturing complementary information on the brain's physiological state. Here we exploited PET/MR simultaneous imaging to explore the relationship between the metabolic information provided by resting-state fluorodeoxyglucose-PET (FDG-PET) and fMRI (rs-fMRI) in patients with disorders of consciousness.

NCT ID: NCT04139239 Completed - Clinical trials for Disorder of Consciousness

Diagnostic Accuracy of the Vegetative and Minimally Conscious State

Start date: July 1, 2017
Phase:
Study type: Observational

The aim of this study was to investigate diagnostic accuracy of the vegetative and minimally conscious state: Clinical consensus versus standardized neurobehavioral assessment