Clinical Trials Logo

Clinical Trial Summary

Microbiota consists of trillions of microorganisms located in all the biological cavity. The relationships between individual health status and microbiota are based on a sort of "mutual cooperation." The balance of the microbiota can be compromised by various factors such as environmental, psycho-physical stress, malnutrition (over or low), breastfeeding, chronic diseases, oncology and pharmacological treatments (especially antibiotics and chemotherapics). The impact of dysbiosis on today's society affects over 70% of the world population


Clinical Trial Description

Intestinal microbiota is defined as the strongest modulator of the human genome and it is considered the "second brain" of our organism for its bi-directional communication with the central nervous system. Microbiota consists of trillions of microorganisms located in all the biological cavity, In the intestine it is distributed in ecological niches having multiple metabolic activities which influence individual health. Microbiota acts as barrier against pathogens, regulating the absorption of nutrients, the production of energy and the development of the immune system4. Intestinal bacteria are generally divided into 4 Phylum: Firmicutes, Actinobacteria, Proteobacteria and Bacteriodetes, in which their proportion shows a correlation with individuals health status. When in equilibrium among them, these bacteria are essential for the good health of the digestive tract, the good function of immune system and for brain performace. The relationships between individual health status and microbiota are based on a sort of "mutual cooperation." The balance of the microbiota can be compromised by various factors such as environmental, psycho-physical stress, malnutrition (over or low), breastfeeding, chronic diseases, oncology and pharmacological treatments (especially antibiotics and chemotherapics). This disequilibrium leads to altered capability of bacteria to properly extract calories from food affecting the trend of many pathophisilogical status such as obesity, allergic states, inflammatory bowel syndromes cardiovascular diseases, metabolic, oncological and neurodegenerative diseases. The impact of dysbiosis on today's society affects over 70% of the world population ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03388424
Study type Observational
Source University of Catanzaro
Contact Luca Gallelli, MD
Phone +390961712322
Email gallelli@unicz.it
Status Recruiting
Phase
Start date November 22, 2017
Completion date November 21, 2022

See also
  Status Clinical Trial Phase
Completed NCT00767702 - Use of Population Descriptors in Human Genetic Research
Recruiting NCT05608096 - European Registry for Hemadsorption in Sepsis With the Seraph Filter
Completed NCT02868177 - Effect of Totum-63, Active Ingredient of Valedia, on Glucose and Lipid Homeostasis on Subjects With Prediabetes Phase 2/Phase 3
Completed NCT05564559 - Multifamily Group Psychoeducation for SUD's in Turkey N/A
Enrolling by invitation NCT03337893 - Investigation of Breastfeeding Protection Against Infant Infections and Childhood Diseases N/A
Completed NCT03722459 - Novel MRI Sequence- MR Fingerprinting N/A
Not yet recruiting NCT06271538 - Evaluation of Efficacy of Skål Pro Powder on Symptoms of Irritable Bowel Syndrome Phase 4
Completed NCT03295123 - Outcome of Children Born After Pregnancy Denial
Terminated NCT04639310 - XEN496 (Ezogabine) in Children With KCNQ2 Developmental and Epileptic Encephalopathy Phase 3
Not yet recruiting NCT05853991 - Effects of Touch on Brain Connectivity and Metabolic Biomarkers in Preterm Infants N/A
Active, not recruiting NCT02195778 - Assessment of Health Literacy Among Adult Patients in the United Arab Emirates to Facilitate Clinical Trials Recruitment. N/A
Recruiting NCT06081452 - Public Survey on Breath Testing for Health and Disease
Recruiting NCT04973774 - A Multi-center Prospective Study of Branch Atheromatous Disease in China
Not yet recruiting NCT04866732 - Physical Activity Program for Cardiac Health Among Older African American Populations N/A
Completed NCT01043133 - Study of Medical Student Use of Templates to Document Outpatient Asthma Care in Electronic Medical Record N/A
Recruiting NCT01317979 - Asian Diabetes Surgery Study (ADSS): Clinical Predictor for the Success of Metabolic Surgery N/A
Recruiting NCT06036433 - Light Therapy Plus Exercise to Improve Motor, Non-Motor Symptoms and QoL in Parkinson's Disease N/A
Completed NCT05214534 - Contribution of SuPAR for Patients in a Situation of Uncertainty Downstream of Emergencies
Completed NCT05930626 - Biomarkers of Acrylamide, Glycidol, POPs, PFAS and Disease Outcomes and OMICs Signatures
Completed NCT04210713 - Neuroimmune Dysfunction in Alcohol Use Disorder Phase 1