Reduced MBF Regimen for Patients >=55 Years With Myeloid Malignancies

Disease-free Survival Clinical Trial

Official title:
A Multiple-center Phase II Study to Evaluate the Clinical Outcome of Reduced Conditioning Regimen With Melphalan, Busulfan and Fludarabine for Patients >=55 Years With Myeloid Malignancies.

Status Recruiting

Clinical Trial Summary

In this multiple-center phase II study, the aim is to evaluate the clinical outcome of reduced intensity conditioning regimen with fludarabine (150mg/m2), busulfan (6.4mg/kg) and melphalan (100mg/m2) in patients with myeloid malignancies including AML, MDS and CMML >=55 years.

Clinical Trial Description

Conditioning regimen with double alkylating agents such as busulfan + melphalan or Busulfan + thiotepa have been shown to improve the transplantation outcome in terms of lower relapse rate in various myeloid malignancies. In this multiple-center phase II study, the aim is to evaluate the clinical outcome of reduced intensity conditioning regimen with fludarabine (150mg/m2), busulfan (6.4mg/kg) and melphalan (100mg/m2) in patients with myeloid malignancies including AML, MDS and CMML >=55 years. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05436561
Study type	Interventional
Source	Shanghai Jiao Tong University School of Medicine
Contact	Jieling Jiang
Phone	+8613311986505
Email	jiangjieling66@hotmail.com
Status	Recruiting
Phase	Phase 2
Start date	June 1, 2022
Completion date	January 1, 2025

View Details

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