Combination of Olmesartan Effect on Myocardial Viability of Patients With Dilated Cardiomyopathy

Dilated Cardiomyopathy Clinical Trial

Official title:

Olmesartan Effect on Myocardial Viability of Patients With Dilated Cardiomyopathy

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04174456
• Other study ID #: 18-215
• Status: Recruiting
• Phase: N/A
• Start date: December 1, 2019
• Est. completion date: December 31, 2021

Study information

• Verified date: August 2020
• Source: Dong-A University
• Contact: Kyung-Mi Ko
• Phone: 82-51-240-5740
• Email: kkmcrc[@]naver.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The study proceeds with prospective, randomized, open and controlled clinical trials. The subject of the investigator's study was the first patient diagnosed with dilated cardiomyopathy. Subjects who agreed to participate in the study and were determined to meet the selection / exclusion criteria were randomly assigned to each group, and the experimental group was treated with 20 mg of olmesartan and 5 mg of rosuvastatin for 6 months, and the control group is treated with 40 mg of valsartan and 5 mg of rosuvastatin.

Description:

Myocardial viability plays an important role in improving the function of the heart. To date, the most reproducible and objective method has been established as a method or tool for assessing myocardial viability.

Olmesartan is known to have the strongest inhibitory ability of angiotensin receptors compared with other angiotensin receptor binding inhibitors. Research has been reported that statin drugs may help improve vascular endothelial function, and several researchers have suggested that these mechanisms may affect the improvement of myocardial survival. In addition, studies have shown that angiotensin receptor binding inhibitors and statins may improve left ventricular function in patients with left ventricular function. However, since the studies did not assess myocardial survival, the mechanisms could not be clearly identified.

The purpose of this study is to investigate the effect of olmesartan on myocardial survival in patients with dilated cardiomyopathy who have left ventricular dysfunction.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 40
• Est. completion date: December 31, 2021
• Est. primary completion date: December 1, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• dilated cardiomyopathy

Exclusion Criteria:

• contraindication to angiotensin receptor blocker

• cardiogenic shock

• sensitive to rosuvastatin

• liver cirrhosis more than Child class B

Related Conditions & MeSH terms

• Cardiomyopathies
• Cardiomyopathy, Dilated
• Dilated Cardiomyopathy

Intervention

Diagnostic Test:
• FDG PET
baseline and 6-month follow-up FDG PET

Locations

Country	Name	City	State
Korea, Republic of	Department of Internal Medicine,Dong-A University College of Medicine	Busan

Sponsors (1)

Lead Sponsor	Collaborator
Dong-A University

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Rate of glucose metabolism	data from fludeoxyglucose positron emission tomography	6 month