Clinical Trials Logo

Diffuse Midline Glioma (DMG) clinical trials

View clinical trials related to Diffuse Midline Glioma (DMG).

Filter by:
  • None
  • Page 1

NCT ID: NCT04732065 Recruiting - Glioblastoma Clinical Trials

ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors

PNOC023
Start date: August 23, 2021
Phase: Phase 1
Study type: Interventional

This phase I trial studies the effects and best dose of ONC206 alone or in combination with radiation therapy in treating patients with diffuse midline gliomas that is newly diagnosed or has come back (recurrent) or other recurrent primary malignant CNS tumors. ONC206 is a recently discovered compound that may stop cancer cells from growing. This drug has been shown in laboratory experiments to kill brain tumor cells by causing a so called "stress response" in tumor cells. This stress response causes cancer cells to die, but without affecting normal cells. ONC206 alone or in combination with radiation therapy may be effective in treating newly diagnosed or recurrent diffuse midline gliomas and other recurrent primary malignant CNS tumors.