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Clinical Trial Summary

The REMIT (RE-irradiation of diffuse MIdline glioma paTients) study evaluates safety and the palliative efficacy of re-irradiation of patients with diffuse midline glioma (DMG). The study will introduce a standard re-irradiation treatment schedule for DMG patients who have progressed following primary treatment.


Clinical Trial Description

REMIT is a non-randomized, prospective, investigator-initiated, phase II, multi-centre observational study with two inclusion groups, arm A and B. Arm A and B will be offered the same treatment. Patients treated with primary radiotherapy 54Gy/30 fractions, either enrolled in the BIOMEDE 2.0 protocol or not, will be included in Arm A. DMG patients treated with any other total dose and fractionation than 54Gy/30F will be included in Arm B. The re-RT and follow up will be the same in both arms. As treatment 20Gy/10 fractions is given as first time re-irradiation with extended follow up on toxicity, performance status and quality of life. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06093165
Study type Interventional
Source Rigshospitalet, Denmark
Contact Daniella Østergaard
Phone +4520822297
Email daniella.elisabet.oestergaard.01@regionh.dk
Status Not yet recruiting
Phase N/A
Start date October 2023
Completion date November 2029

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