Dietary Modification Clinical Trial
Official title:
Evaluation of Absorption and Metabolism of Phenolic Compounds From Mangoselect®, an Extract of Mangosteen. Comparison of Two Versions During a Randomized, Double-blinded and Cross-over Trial
The aim of this study is to compare pharmacokinetics and bioavailability of phenolic
compounds, mainly xanthones, from a mangosteen extract, either ingested in a dry powder form
or in an encapsulated form. Absorption and metabolism will be determined by measuring urinary
excretion of phenolic metabolites and blood metabolic profile over 72 hours by means of High
Pressure Liquid Chromatography (HPLC) coupled with tandem mass spectroscopy.
The design of this study is a cross-over, double-blind and randomized trial on 10 healthy
subjects.
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