Effects of L-arginine and L-citrulline Supplementation on Muscle Respiration

Dietary Exposure Clinical Trial

Official title: The Effect of L-arginine and L-citrulline Supplementation on Endurance Performance and Mitochondrial Respiration

Status Completed

Clinical Trial Summary

The objective of this trial is to determine the effects of dietary supplementation with the amino acids, L-arginine and L-citrulline, on endurance performance and mitochondrial respiration in healthy men compared to supplementation with L-arginine alone and a placebo supplement.

Clinical Trial Description

This study is a randomized, double-blind, cross over trial of L-arginine and L-citrulline supplementation, L-arginine supplementation alone and placebo supplementation in healthy men. The intervention period will be 8-11 weeks for each participant and a minimum of 15 individuals will be recruited and enrolled to complete the trial. Subjects will complete the experimental protocol described below over 3 individual 10 day supplementation periods, separated by washout periods of approximately 2 weeks. Subjects will ingest corn-starch as a placebo, L-arginine (3g/day) or L-arginine (1.5 g/day) + L-citrulline (1.5g/day). On day 7 of the supplementation period, a skeletal muscle biopsy and blood sample will be obtained from the subjects to investigate mitochondrial function and blood amino acid and nitric oxide levels. On day 10 of the supplementation period, subjects will complete a performance test on a cycle ergometer to investigate their endurance performance. These assessments will be performed to determine the effects of co-ingesting L-arginine and L-citrulline compared to L-arginine alone and placebo administration. ;

Related Conditions & MeSH terms

• Dietary Exposure

• NCT number: NCT03998800
• Study type: Interventional
• Source: Loughborough University
• Status: Completed
• Phase: N/A
• Start date: May 1, 2019
• Completion date: January 1, 2022