Randomized Multicentric Trial to Evaluate a Free Diet With a Progressive Diet in the Treatment of Acute Diverticulitis (DIVERDIET)

Diet Modification Clinical Trial

Official title:

Randomized Multicentric Controlled Clinical Trial of Parallel Groups to Evaluate the Non-therapeutic Inferiority of a Free Diet With a Progressive Diet, in the Treatment of Non-complicated Acute Diverticulitis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03496090
• Other study ID #: DIVERDIET
• Status: Completed
• Phase: N/A
• Start date: April 16, 2018
• Est. completion date: April 16, 2019

Study information

• Verified date: August 2019
• Source: Hospital General Universitario Reina Sofía de Murcia
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Phase III trial is designed to demonstrate the non-inferiority of a free diet versus a progressive diet in the treatment of acute diverticulitis (AD) without complications. In this study, the effectiveness of the short-term free diet is evaluated, as well as its safety and the quality of life that is perceived in front of the progressive diet.

Description:

The study will be carried out in the General Surgery and Gastroenterology Services of the following centers:

• Hospital General Universitario Reina Sofía

• Hospital General Universitario Morales Meseguer de Murcia.

• Hospital Universitario Santa Lucía de Cartagena.

• Hospital General Universitario de Elche.

• Complejo Hospitalario Torrecárdenas de Almería

All patients with increased temperature and acute abdominal pain, as well as clinical suspicion of AD, will be screened for their potential selection in the study. Basic blood tests (hemogram) and abdominal ultrasound will be performed and these guidelines will be followed: if the results indicate complicated AD, it will be excluded from the study; if uncomplicated DA is suspected, blood CRP will be requested; if CRP is less than 5 mg / dl, it will be included in the study and ambulatory treatment will be indicated; if CRP is greater than 5mg / dl, abdominal CT with intravenous contrast will be requested. Result: uncomplicated DA, it will be included in the study and it will be indicated ambulatory treatment or complicated DA, it will be excluded from the study-; those patients with uncomplicated AD, but with risk factors, hospital admission will be recommended, and they may be offered to participate in the study.

If the patient meets the criteria for admission to the study, the attending physician (surgeon on duty) will inform and invite them to participate and after signing the informed consent, their data will be collected and they will be contacted. the person of the hospital, in charge of guarding the list and randomization codes to assign him the corresponding research group: group 1 (free diet) or group 2 (progressive diet) (Annex III), - this group will be delivered of your printed diet and you will be instructed about it, as well as, to all patients, the annotations of pain control and temperature on ad-hoc sheet. The patient data will be delivered to the investigator / s of the study of each hospital, who will fill in the Data Collection Notebook (DCN) of each patient and program their controls without information of the group to which the patient has been assigned, as In this way, the consultations are carried out with blinding of the evaluator (the investigator who will do the controls will not know to which group the patient has been assigned). They will also be asked a quality of life questionnaire SF-12 (baseline) and they will be asked for a blood test with a complete blood count and CRP for the 3rd day of treatment.

Outpatients will be contacted daily by phone during the first 3 days of treatment by the study investigator and between the 3rd and 4th day will go to outpatient surgery for clinical and analytical control (1st consultation), filling in the DCN. The hospitalized patients will follow the same clinical and analytical control by the plant surgeon and the study investigator, filling in the DCN. They will be asked for new blood tests with CRP for the 7th day of treatment and, in those patients who do not have a colonoscopy in the last 12 months prior to entering the study, an endoscopic study will be requested before 60 days for confirmation of diverticular disease, filling in the DCN. They will be given a new SF-12 quality of life questionnaire that they will fill out on the 7th day of the start of the treatment. They will be cited for a new consultation (2nd consultation) to all patients (outpatients and those who have been hospitalized), 30 days of the beginning of the treatment, with new clinical control and annotation of the last analytical, as well as third and last SF-12 quality of life questionnaire, in the DCN. To conclude, patients who were asked for colonoscopy, will be cited in a final consultation (3rd) 2 months after beginning the treatment with the endoscopic result closing the study, with the last entries in the DCN.

Sample size:

To obtain a power of 80% to reject the null hypothesis Ho: that the difference of proportions p1 and p2 is lower than the non-inferiority limit of -10, and taking into account that the level of significance is 5%, assuming that the proportion of non-treatment failure in both treatment groups is 94.7%, the total number of patients expected to be included in the study is 134 patients, with an expected percentage of dropouts of 5%, which 67 patients will receive treatment through free diet and other 67 patients through progressive diet. The endpoint for the main comparison is the proportion of subjects with a lower treatment failure rate at one month (30 days) of follow-up.

Statistical treatment:

The continuous variables will be summarized using descriptive statistics: mean, standard deviation (SD), median, minimum, maximum, number of observations and number of missing observations. Non-normal continuous data will be presented as maximum, top quartile, median, lowest quartile, minimum and number of observations. The categorical variables will be described using absolute and relative frequencies.

For the comparisons between variables, the bivariate analysis will be used. The scores of each dependent variable will be compared with the independent variables using parametric statistical methods (and nonparametric when the parametric application criteria are not met). When the changes within the same treatment group are analyzed, statistical tests for related or paired samples will be used.

In the event that the variables follow the normal distribution, one or more of the following techniques will be described:

• If a variable is of a quantitative type and the other is categorical, for the comparison of the means with a dichotomous variable, the Student's t test will be used. In cases where the qualitative variable has more than 2 categories, the one-way variance analysis (ANOVA) will be used. In the analysis of the variance of a factor with repeated measures, it will be assumed that the subjects are randomly selected from normal populations with the same variance. Previously, the assumptions of independence, normality and equality of variances will be checked.

In the case that the variables do not follow the normal distribution:

• If one variable is quantitative and the other qualitative, the test to be applied will be the Mann-Whitney U test when the qualitative variable has 2 levels, and the Kruskall-Wallis test if the qualitative measurement is formed by 3 levels or plus.

• If both variables are of the categorical type, a cross-tabulation will be performed (contingency tables) using the Pearson chi-square statistic to test the independence hypothesis or the Fisher test (in 2 x 2 tables) ). An analysis of typed residuals corrected will be carried out in order to interpret the meaning of the association detected.

For the non-inferiority analysis in the main variables, a calculation will be made using the Farrington-Manning score, Miettinen-Nurminen Score and Gart-Nam Score tests, with a significance level of 0.05, and a limit of no- inferiority of 0.10. For the continuous variables, non-inferiority will be evaluated by the difference of means with the Mann-Whitney U and the Wilcoxon test.

All statistical comparisons will be made using statistical tests with a level of significance p = 0.05.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 134
• Est. completion date: April 16, 2019
• Est. primary completion date: January 31, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Diagnosis of uncomplicated acute diverticulitis

• Adequate oral tolerance

• Good response to the first emergency treatment measures (analgesics and antibiotic therapy): improvement of pain and decrease in temperature.

• Willing to continue treatment at home under supervision.

• Accept sign informed consent.

Exclusion Criteria:

• Acute complicated diverticulitis (from grade Ib of the modified Hinchey Classification).

• No good response to the first emergency treatment measures (analgesics and antibiotics): maintenance or increase of abdominal pain, persistence of fever, oral intolerance or vomiting, clinical worsening.

• Antibiotic treatment for diverticulitis in the previous month.

• Suspicion of colorectal cancer.

• Pregnant.

• Refuses to sign informed consent.

Related Conditions & MeSH terms

• Acute Diverticulitis
• Diet Modification
• Dietary Modification
• Diverticulitis
• Diverticulitis of Sigmoid
• Diverticulitis, Colonic
• Diverticulum
• Uncomplicated Diverticular Disease

Intervention

Other:
• Free diet
Free diet or free demand, being comparable to the normal or zero hospital diet
• Progressive diet
Progressive diet for 7 days, liquid diet for the first three days and soft diet without waste, from the 4th to the 7th day.

Locations

Country	Name	City	State
Spain	Hospital General Universitario Reina Sofía	Murcia

Sponsors (1)

Lead Sponsor	Collaborator
Hospital General Universitario Reina Sofía de Murcia

Country where clinical trial is conducted

Spain, 

References & Publications (41)

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* Note: There are 41 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Success in the treatment	Absence of persistence, increase or recurrence of abdominal pain or fever, transition to a stage higher than that of the modified Hinchey classification (requiring radiological drainage and / or surgical treatment), need for hospital admission (for outpatients) and death attributed to this diagnosis.	30 days
Secondary	Pain score	The evaluation in each treatment group of pain intensity, using visual analogue scale (VAS) of pain, self-evaluated daily after dinner. Min value 0. Max value 10. Higher values represent a worse outcome.	7 days
Secondary	Body temperature	Axillary temperature curve, as a reference, by one shot every 12 hours.	7 days
Secondary	PCR value	The comparison in each treatment group of the levels of C-reactive protein (CRP).	day 0, 3 and 7
Secondary	Increase in stage	Percentage of patients in each treatment group who pass to a stage higher than Ia in the Hinchey classification modified.	30 days
Secondary	Need for hospital admission	Percentage of outpatients in each treatment group who require hospital admission.	30 days

External Links

•   Diverticular Disease: An Update on Pathogenesis and Management. Gut Liver
•   hospital diets