Insulin Sensitivity Response to High-Intensity Training in Insulin Resistance During Pregnancy

Diet, Healthy Clinical Trial

Official title:

Impact of High-Intensity Interval Training on Insulin Resistance During Pregnancy: A Randomized Control Trial.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04830995
• Other study ID #: Cairo Un100
• Status: Completed
• Phase: N/A
• Start date: March 24, 2020
• Est. completion date: November 1, 2020

Study information

• Verified date: January 2023
• Source: Cairo University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Insulin Resistance is one of the common complications that occur during pregnancy. Early intervention is essential to prevent the development of the diseaseThere is evidence that physical inactivity increases the risk of a lot of adverse health problems, including coronary heart disease, type 2 diabetes, breast and colon cancers. It also shortens life expectancy. Pregnancy is a period in the life of women that is often associated with decreased daily physical activity and decreased participation in sports and exercise . In the first few weeks of pregnancy, maternal carbohydrate metabolism is affected by a rise in maternal levels of estrogen and progesterone that stimulates pancreatic β-cell hyperplasia and insulin secretion. As pregnancy progress, pancreatic islet cell hypertrophy continues and there is an increased insulin response to glucose or meal stimulation.

Description:

This study was carried out upon twenty multigravida pregnant female between 5-6 months gestation with IR calculated by HOMA test (fasting blood glucose× fasting insulin) ÷ 22.5. Fasting blood glucose was assessed by the method approved by (7, 13) .The test materials for this method were supplied as kits by "Diamond Diagnostics," while Insulin concentrations were stated in formerly frozen and defrosted serum samples by enzyme immunoassay using the human Insulin ELISA kits.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: November 1, 2020
• Est. primary completion date: October 30, 2020
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 25 Years to 35 Years

Eligibility

Inclusion Criteria:

• forty multigravida females.

• their age ranged between 25 to 35 years old.

• Body mass index (BMI) <30kg/ m².

Exclusion Criteria:

• females with pelvic pathology as endometriosis.

• females have irregular menstrual cycles.

Related Conditions & MeSH terms

• Diet, Healthy
• High Intensity Interval Training
• Insulin Resistance

Intervention

Dietary Supplement:
• moderate restricted diet (1800-2000 kcal/day) for four weeks
high intensity interval training 3 sessions for four weeks

Locations

Country	Name	City	State
Egypt	Ghada Elrefaye	Giza

Sponsors (3)

Lead Sponsor	Collaborator
Cairo University	Heba mohamed Embaby, Salwa Elgendy

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Fasting blood glucose level	Fasting blood glucose level were measured by expert specialist before and after intervention period from 24th to 37th weeks of pregnancy.	three months
Secondary	Fasting Insulin Level	Fasting blood insulin level were measured by expert specialist before and after intervention period from 24th to 37th weeks of pregnancy.	three months