Effects of a High-fat Meal on Exercise-mediated Sympatholysis

Status Recruiting

Clinical Trial Summary

The goal of this trial is to examine the effects of a single high-fat meal with or without the co-ingestion of dietary nitrate on exercise-mediated sympatholysis. The main questions it aims to answer are: 1. What are the mechanisms responsible for reduced exercise-mediated sympatholysis following a high-fat meal 2. Can dietary nitrate prevent the declines in exercise-mediated sympatholysis Participants will be asked to complete three study visits in a randomized order: 1. Low-fat meal 2. High-fat meal 3. High-fat meal plus dietary nitrate Exercise-mediated sympatholysis will be measured using Doppler ultrasound via a protocol involving rhythmic handgrip exercise and a lower body negative pressure stimulus. Sympatholysis will be assessed before each meal, and at 1, 2, and 3 hours post-prandial.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Diet, Healthy

Clinical Trial Details

NCT number	NCT06186050
Study type	Interventional
Source	University of Guelph
Contact	Philip Millar, PhD
Phone	5198244120
Email	pmillar@uoguelph.ca
Status	Recruiting
Phase	N/A
Start date	January 8, 2024
Completion date	December 30, 2024

View Details

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