Diastolic Function in Myotonic Dystrophy Type 1

Status Recruiting

Clinical Trial Summary

Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder in relation with an unstable expansion of CTG repeat. Patients with DM1 are at risk of arrhythmia and conduction disorders. Mortality are mainly related to respiratory failure and sudden death. Patients with DM1 may suffer from obesity, arterial hypertension, diabetes mellitus and sleep apnea. These comorbidities are classically associated with left ventricular diastolic dysfunction (DD) . The investigators aim to assess the prevalence of left ventricular diastolic dysfunction in patients with myotonic dystrophy type 1 , the distribution of DD grading as well as the long-term prognosis of DM1 patients with a left ventricular diastolic dysfunction.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06029192
Study type	Observational
Source	Centre d'Investigation Clinique et Technologique 805
Contact	Abdallah FAYSSOIL, MD PhD
Phone	+33147107778
Email	abdallah.fayssoil@aphp.fr
Status	Recruiting
Phase
Start date	June 2, 2023
Completion date	November 1, 2023

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04558450` - Covid-19 Effects on Arterial Stiffness and Vascular Aging (CARTESIAN)	N/A
Recruiting	`NCT02499601` - CORolla® TAA for Heart Failure With Preserved Ejection Fraction (HFpEF) and Diastolic Dysfunction (DD)	N/A
Completed	`NCT01775865` - Targeting Inflammation to Treat Cardiovascular Aging	Phase 2
Terminated	`NCT01188369` - Effects of Levosimendan in Patients Eligible for Aortic Valve Replacement With Left Ventricular Hypertrophy	Phase 4
Recruiting	`NCT05552521` - Diastolic Dysfunction in Septic Shock and Cardiomyopathy Genetic Variants
Recruiting	`NCT05438030` - Diastolic Function Assessment With Cardiac Magnetic Resonance Imaging	N/A
Completed	`NCT04128735` - Diastolic Dysfunction in Morbidly Obese Patients Undergo Bariatric Surgery
Completed	`NCT00689819` - Pre-clinical Cardiac Dysfunction Among Asymptomatic Hypertensive Patients	N/A
Recruiting	`NCT04149990` - Angiotensin-Neprilysin Inhibition in Diastolic Dysfunction After AMI	Phase 2
Completed	`NCT03768752` - Diastolic Dysfunction and Interstitial Lung Edema in Septic Patients
Completed	`NCT02932436` - Effects of Empagliflozin on Left Ventricular Diastolic Function Compared to Usual Care in Type 2 Diabetics	Phase 4
Recruiting	`NCT05847244` - The Effect of Addition of Metformin In Obese Non- Diabetic Patients With Heart Failure With Preserved Ejection Fraction	Phase 2
Enrolling by invitation	`NCT04190420` - The Transition From Hypertension to Hypertensive Heart Disease and Heart Failure, the PREFERS Hypertension Study
Completed	`NCT04114474` - Pre-operative Focused Transthoracic Echocardiography for Prediction of Post-operative Cardiac Complications
Not yet recruiting	`NCT06131008` - Diastology-Guided Management of Decompensated Heart Failure	N/A
Completed	`NCT03110614` - Diastolic Dysfunction and Pauci-inflammatory Acute Exacerbations of COPD
Not yet recruiting	`NCT02285309` - Perioperative Measurements of Diastolic Function in Cardiac Surgery	N/A
Completed	`NCT01761318` - Effect of Liraglutide on Cardiovascular Endpoints in Diabetes Mellitus Type 2 Patients	Phase 4
Completed	`NCT00907439` - Study of the Effect of Inhaled Anesthetics on Diastolic Heart Function Using a Doppler-derived Efficiency Index	N/A
Completed	`NCT00804518` - Effect of Exercise on Heart Function in Healthy Elderly People	N/A