Diagnosis Clinical Trial
Official title:
Dual Tracer Functional Imaging of Nonfunctional Pancreatic Neuroendocrine Tumors Using 68Ga-DOTA-NOC and 18F-FDG PET/CT
Predicting aggressive behavior in the group of nonfunctional pancreatic neuroendocrine
tumors (NF P-NET) remains a difficult problem in clinical practice. At present, the
treatment planning in P-NET is significantly restricted by the limited results of
conventional imaging. In addition, increasing use of multidetector computed tomography
(MDCT) and magnetic resonance imaging (MRI) is increasing the number of NF P-NETs detected.
Somatostatin receptor scintigraphy (SRS) combined with anatomical imaging are the
conventional modalities in imaging of P-NET, but by these methods the diagnostic accuracy
still remains compromised. Furthermore, recently encouraging results have been obtained in
P-NET using 68Ga-labelled somatostatin analog, DOTA-1-NaI3-octreotide (68Ga-DOTANOC)
positron emission tomography-computed tomography (PET-CT).
The aim of the current project is to evaluate the possibility to enhance the diagnostic
accuracy by using dual trace functional imaging 18F-labelled fluorodeoxyglucose (18F-FDG)
and 68Ga-DOTANOC PET-CT imaging in patients with NF P-NET. The study consists of 20 patients
with NF P-NET. The patients enrolled in the study will be imaged 68Ga-DOTANOC and 18F-FDG
PET-CT followed by surgery or follow-up with endoscopic ultrasonography (EUS) biopsies. The
data will be collected between autumn 2015 and spring 2018.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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