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Diabetic Peripheral Neuropathy clinical trials

View clinical trials related to Diabetic Peripheral Neuropathy.

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NCT ID: NCT05258240 Completed - Clinical trials for Diabetic Peripheral Neuropathy

Effects of Virtual Reality-based Balance Training on Balance of Diabetic Peripheral Neuropathy Patients

Start date: March 1, 2021
Phase: N/A
Study type: Interventional

The study aimed to clarify the effect of virtual reality-based balance training on balance in patients with diabetic peripheral neuropathy compared to conventional physical therapy.

NCT ID: NCT05162690 Recruiting - Clinical trials for Diabetic Peripheral Neuropathy

Efficacy of Dapagliflozin in Diabetes Associated Peripheral Neuropathy

DINE
Start date: May 1, 2022
Phase: Phase 2/Phase 3
Study type: Interventional

Diabetic peripheral neuropathy(DPN) is a length dependent axonal neuropathy that affects at least 50% of patients with diabetes mellitus. DPN is often asymptomatic during the early stages of diabetes ,however, once symptoms and overt deficits have developed, it cannot be reversed. Early diagnosis of neuropathy is important because early diagnosis and timely intervention might prevent the development and progression of diabetic neuropathy.Though glycemic control has been shown to prevent the progression of diabetic microvascular complications including diabetic peripheral neuropathy in Type I DM, such strict glycemic control has not shown to improve diabetic peripheral neuropathy in Type 2 DM. There are only few animal studies conducted so far which have shown that the use of SGLT2 inhibitors prevents the progression of diabetic peripheral neuropathy.Thus the investigators postulate that the use of SGLT2 inhibitor in patients with Type 2 Diabetes Mellitus might be beneficial in the prevention of progression of diabetic peripheral neuropathy as well as reverse it.

NCT ID: NCT05118217 Not yet recruiting - Clinical trials for Diabetic Peripheral Neuropathy

Microvascular Dysfunction in Diabetic Peripheral Neuropathy

Start date: November 18, 2021
Phase:
Study type: Observational

This study primarily seeks to evaluate dysfunction of small blood vessels and their linkage to dysfunction of nerves in people with Type 2 Diabetes. The purpose of this research is to explore some of the underlying pathophysiology of diabetic peripheral neuropathy, particularly painful diabetic peripheral neuropathy. The pain experienced by individuals with painful diabetic peripheral neuropathy is severe and associated with low quality of life. The pain does not typically respond well to pharmacological management. The processes underpinning the sources of pain are poorly understood, consequently only around a third of patients benefit from existing treatments. Some historic research on the sources of pain suggest the retention of the ability to reduce blood flow in small vessels may underpin these pain pathways. This research aims to explore this possibility, looking at the nerve-linked response in small vessels with a flickering light within the eye. Participants will complete three or four questionnaires: one demographic, two to aid with stratifying participants into groups concerning symptoms of neuropathy and an additional questionnaire if participants are stratified to the painful DPN group. A basic neurological examination of the feet will follow. Basic measurements of height, weight and blood pressure will be recorded for each participant. The primary sites of measurement of this small vessel dysfunction will be the eye and the foot investigated in a non-invasive manner. A bright flickering light will be shone into participants eyes, with the reaction of small vessels recorded. Sensors will also be placed on the feet and chest of participants and warmed to ~44C. An image will be taken of participants eyes to measure nerve layer thickness and an area of skin on the forearm will be illuminated to measure for levels of a metabolic marker. A picture of the eye will also be taken to determine nerve layer thickness.

NCT ID: NCT05041816 Withdrawn - Clinical trials for Diabetic Peripheral Neuropathy

Peripheral Nerve Responses to Focal Vibration and Implications in Pain and Mobility for Patients With Diabetic Peripheral Neuropathy

Start date: September 1, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to characterize the changes in peripheral nerve functions (sensory and motor) in patients with diabetic peripheral neuropathy, and examine the relations between the changes in nerve functions and changes in pain and mobility using focal vibration.

NCT ID: NCT04984044 Completed - Clinical trials for Diabetic Peripheral Neuropathy

Effect of Vitamin D in Patients With Diabetic Peripheral Neuropathy to Alleviate Pain and Improvement of Symptoms

Start date: November 7, 2020
Phase: N/A
Study type: Interventional

Diabetic peripheral neuropathy(DPN) is one of the major complications of diabetes mellitus which accelerates the occurrence of ulceration of diabetic foot and amputation of lower extremities as well as severely affects the quality of life. The treatment of this condition has remained unsatisfactory with a good response to conventional medications. It is now evident that vitamin D deficiency is common in diabetic patients and especially in these patients diagnosed with diabetic peripheral neuropathy. The present research is therefore designed to observe the effect of exogenous administration of vitamin D in diabetic peripheral neuropathy patients of Bangladesh.

NCT ID: NCT04873232 Recruiting - Clinical trials for Diabetic Peripheral Neuropathy

A 6-Month Extension Study of VMDN-003-2 to Assess Engensis in Participants With Painful Diabetic Peripheral Neuropathy

REGAiN-1B
Start date: May 17, 2021
Phase: Phase 3
Study type: Interventional

To evaluate the durability of efficacy and long-term safety of intramuscular (IM) administration of Engensis or Placebo that was administered in the double-blind, randomized, VMDN-003-2 Placebo-controlled Phase 3 Study.

NCT ID: NCT04846673 Recruiting - Clinical trials for Diabetic Peripheral Neuropathy

Pregabalin and Alpha-lipoic Acid Combination Versus Each Monotherapy in Patients With Diabetic Peripheral Neuropathy

OPTIMUM
Start date: May 14, 2021
Phase: Phase 4
Study type: Interventional

This study is a randomized, parallel, open-label, multicenter, phase IV clinical trial to assess the efficacy and safety of pregabalin and alpha-lipoic acid combination compared with each monotherapy in patients with diabetic peripheral neuropathy for 12 weeks.

NCT ID: NCT04807452 Completed - Clinical trials for Diabetic Peripheral Neuropathy

Strength And Balance Training on Diabetic Peripheral Neuropathy

Start date: March 30, 2020
Phase: N/A
Study type: Interventional

A Randomized Control Trial was conducted on 20 participants, equally allocated in strength plus balance and aerobic group from February-2020 until December-2020.Participants were selected according to inclusion and exclusion criteria on purposive sampling technique and randomization was done by sealed envelope method. Inclusion criteria was both gender, 40 years to 80 years, Patients with type 2 diabetes ,diabetic peripheral neuropathy and Toronto neuropathy score 6 or greater. Participants were assessed after taking consent before and after 12 sessions through Toronto clinically neuropathy system, SF-36 and berg balance scale. Data was analyzed using SPSS v.22.

NCT ID: NCT04720170 Not yet recruiting - Clinical trials for Diabetic Peripheral Neuropathy

Exploratory Study of the Efficacy of Standard of Care Revascularization of the Lower Extremity

Start date: February 15, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the efficacy of the standard of care revascularization of the lower extremity with the addition of revascularization of the lateral plantar artery and anterior pedal loop of the foot as treatment for diabetic peripheral neuropathy.

NCT ID: NCT04688671 Completed - Clinical trials for Diabetic Peripheral Neuropathy

Efficacy and Safety of ETX-018810 for the Treatment of Diabetic Peripheral Neuropathic Pain

Start date: November 9, 2020
Phase: Phase 2
Study type: Interventional

A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Parallel-Group Study to Evaluate the Efficacy and Safety of ETX 018810 in Subjects with Diabetic Peripheral Neuropathic Pain.