Diabetes Mellitus Clinical Trial
Official title:
Prevalence of Diabetes Among Hospitalized Patients With Covid-19 in West of Algeria. Identification of Diabetes-related Associated Factors Severe Forms
By Jan 7, 2020, Chinese scientists had isolated a novel coronavirus, from patients with
virus-infected pneumonia. The WHO designated later this virus as COVID-19 (coronavirus
disease 2019). This exponential pandemic coronavirus infection is responsible for severe
forms in 15 to 20%, for critical ill requiring ventilation in 5% and for mortality in 2%.
Algeria was part of the 13 top priority countries identified by WHO based on their direct
links and volume of travel to the infected provinces in China.
It is known that some predisposing conditions lead to a worse outcome with coronavirus.
In China, the overall case-fatality rate was 2.3%, but was higher in patients with diabetes
(7.3%). In Italy, the most common comorbidities associated with death from COVID-19 were
hypertension (73.8%) and diabetes (33.9%). The US Centers for Disease Control and Prevention
suggests diabetes is the most common comorbidity in COVID-19 cases. In the largest cohort NHS
England study, death from COVID-19 was strongly associated with uncontrolled diabetes (after
full adjustment, HR 2.36).
The West Algerian CORODIAB-13 study aims is (1) to assess the prevalence of diabetes among
hospitalized patients with Covid-19, (2) to describe the phenotypic characteristics of
patients with diabetes, and (3) to identify the parameters specific to the diabetic which are
associated with severe forms.
In the future, this study will provide answers for two main questions
1. Why diabetics are more at risk of developing Covid-19 infection?
2. Why diabetics are at high risk of developing severe forms?
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