Clinical Trials Logo
  1. Home
  2. Diabetes Mellitus, Type 2
  3. NCT04011228
  4. Details
NCT04011228 Clinical Trial

Epigenetics Based Diagnosis of Diabetes in Saliva and Blood Samples

Diabetes Mellitus, Type 2 Clinical Trial

Official title:
Sex-specific Relationship of Epigenetics Based Modifications in the Saliva and Blood With the Occurence of Type 2 Diabetes

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT04011228
Other study ID # EPI-1090
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date February 29, 2016
Est. completion date January 1, 2020

Study information
Verified date August 2019
Source Medical University of Vienna
Contact Alexandra Kautzky-Willer, Univ.Prof.Dr.
Phone +434040021260
Email alexandra.kautzky-willer@meduniwien.ac.at
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The aim of the present study is to investigate epigenetics based modifications and biomarkers in the saliva and blood in diabetic patients.

Recruitment information / eligibility
Status Recruiting
Enrollment 224
Est. completion date January 1, 2020
Est. primary completion date December 11, 2019
Accepts healthy volunteers
Gender All
Age group 18 Years to 75 Years
Eligibility Inclusion Criteria:

- type 2 diabetic patients

- prediabetic patients

- women with gestational diabetes

- healthy control subjects without diabetes

- healthy pregnant women

Exclusion Criteria:

- cancer disease

- infectious diseases such as hepatitis or HIV

- malignoms

- patients with claustrophoby

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• Blood sampling
After a fasting period over night blood samples will be taken.
• Saliva and blood samples
After a fasting period over night blood and saliva samples will be taken for the investigation of epigenetics based modifications.
• Magnet Resonance Spectroscopy
The amount of ectopic lipids in the liver, heart and the skeletal muscle will be measured using 1H-magnetic resonance spectroscopy.

Locations
Country Name City State
Austria Medical University of Vienna Vienna

Sponsors (1)
Lead Sponsor Collaborator
Medical University of Vienna

Country where clinical trial is conducted

Austria, 

Outcome
Type Measure Description Time frame Safety issue
Primary Specifying the microRNAs in saliva in diabetic patients Characterization of microRNAs in saliva of prediabetic and type 2 diabetic patients, as well as in women with gestational diabetes and healthy control subjects. 1 hour
Secondary Correlation of the percentage of liver fat with miRNA´s in diabetic patients. Correlation of miRNA´s in the saliva with the amount of intrahepatic liver fat. 1 hours
Secondary Correlation of the percentage of heart fat with miRNA´s in diabetic patients Correlation of miRNA´s in the saliva with the amount of ectopic lipids in the heart. 1 hour
Secondary Correlation of the percentage of the content of fat in the skeletal muscle with miRNA´s in diabetic patients. Correlation of miRNA´s in the saliva with the amount of ectopic lipids in the skeletal muscle. 1 hour
See also
  Status Clinical Trial Phase
Active, not recruiting NCT05666479 - CGM Monitoring in T2DM Patients Undergoing Orthopaedic Replacement Surgery
Completed NCT05647083 - The Effect of Massage on Diabetic Parameters N/A
Active, not recruiting NCT05661799 - Persistence of Physical Activity in People With Type 2 Diabetes Over Time. N/A
Completed NCT03686722 - Effect of Co-administration of Metformin and Daclatasvir on the Pharmacokinetis and Pharmacodynamics of Metformin Phase 1
Completed NCT02836704 - Comparison of Standard vs Higher Starting Dose of Insulin Glargine in Chinese Patients With Type 2 Diabetes (Glargine Starting Dose) Phase 4
Completed NCT01819129 - Efficacy and Safety of FIAsp Compared to Insulin Aspart in Combination With Insulin Glargine and Metformin in Adults With Type 2 Diabetes Phase 3
Completed NCT04562714 - Impact of Flash Glucose Monitoring in People With Type 2 Diabetes Using Non-Insulin Antihyperglycemic Therapy N/A
Completed NCT02009488 - Treatment Differences Between Canagliflozin and Placebo in Insulin Secretion in Subjects With Type 2 Diabetes Mellitus (T2DM) Phase 1
Completed NCT05896319 - Hyaluronic Acid Treatment of the Post-extraction Tooth Socket Healing in Subjects With Diabetes Mellitus Type 2 N/A
Recruiting NCT05598203 - Effect of Nutrition Education Groups in the Treatment of Patients With Type 2 Diabetes N/A
Completed NCT05046873 - A Research Study Looking Into Blood Levels of Semaglutide and NNC0480-0389 When Given in the Same Injection or in Two Separate Injections in Healthy People Phase 1
Completed NCT04030091 - Pulsatile Insulin Infusion Therapy in Patients With Type 1 and Type 2 Diabetes Mellitus Phase 4
Terminated NCT04090242 - Impact of App Based Diabetes Training Program in Conjunction With the BD Nano Pen Needle in People With T2 Diabetes N/A
Completed NCT03604224 - A Study to Observe Clinical Effectiveness of Canagliflozin 300 mg Containing Treatment Regimens in Indian Type 2 Diabetes Participants With BMI>25 kg/m^2, in Real World Clinical Setting
Completed NCT03620357 - Continuous Glucose Monitoring & Management In Type 2 Diabetes (T2D) N/A
Completed NCT01696266 - An International Survey on Hypoglycaemia Among Insulin-treated Patients With Diabetes
Completed NCT03620890 - Detemir Versus NPH for Type 2 Diabetes Mellitus in Pregnancy Phase 4
Withdrawn NCT05473286 - A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Germany, as Part of Local Clinical Practice
Not yet recruiting NCT05029804 - Effect of Walking Exercise Training on Adherence to Disease Management and Metabolic Control in Diabetes N/A
Completed NCT04531631 - Effects of Dorzagliatin on 1st Phase Insulin and Beta-cell Glucose Sensitivity in T2D and Monogenic Diabetes Phase 2