High-intensity Interval Training Training Protocols on Cardiorespiratory Parameters in Patients With Type 2 Diabetes

Diabetes Clinical Trial

Official title:

The Effects of Different High-intensity Interval Training Training Protocols on Cardiorespiratory Parameters in Patients With Type 2 Diabetes

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03487029
• Other study ID #: KA17069
• Status: Completed
• Phase: N/A
• Start date: March 2, 2018
• Est. completion date: January 17, 2020

Study information

• Verified date: April 2020
• Source: Hacettepe University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Aim: To assess whether there are different training effects on glucose concentration and cardiorespiratory parameters of different high-intensity training protocols in patients with type 2 diabetes.

Type 2 diabetes is a highly prevalent disease associated with cardiovascular disease leading to high levels of mortality, morbidity and health expenditure, characterized by impaired glucose control during activities and reduced aerobic exercise capacity .

Exercise training is the most effective way to improve compliance, reduce blood glucose concentration and increase insulin sensitivity. Training increases muscle capacity, oxidative capacity and glucose transport, peripheral insulin sensitivity is improved.

Exercise training with high-intensity interval (resting and exercise period) High Intensity Interval Training (HIIT) is a form of exercise training that has recently been widely used in the management of type 2 diabetes, including short duration high intensity exercise periods and lower severity or passive rest periods. There are different HIIT exercise training programs according to physiological responses in the literature. However, long-term and short-term HIIT training training programs were not compared in terms of their effect on glucose concentration and cardiorespiratory fitness. The aim of this study was to compare the effects of different HIIT exercise training programs so that exercise programs for patients with type 2 diabetes could be planned more effectively.

Description:

This study will be participated patients with Type 2 diabetes. Patients' laboratory values, pulmonary function test, respiratory muscle strength, exercise capacity, physical activity level, quality of life will be evaluated.

Pulmonary function test will be assesed with spirometer, respiratory muscle strength will be evaluated with mouth pressure. Exercise capacity will be evaluated using six minute walking test, incremental shuttle walk test, cycle ergometer. Muscle oxigeneration will be asssed with wearable lactate threshold predicting device. Physical activity level will be evaluated trial accelerometer.

Then, patients will be randomly divided two high intensity interval exercise training groups.

First group: short duration high intensity exercise training (Exercise load phase : 30sn %100 Patients performance, rest phase: 120sn %25 patients performance) Second group: Long duration high intensity interval exercise training (Exercise load phase : 4 dk %100 Patients performance, rest phase: 120sn %25 patients performance) All patients will participate three times a week during eight weeks. The muscle oxigeneration, blood glucose consantration, blood pressure, heart rate will be recorded before and after each exercise session. After 8 week, all test will be done again.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 36
• Est. completion date: January 17, 2020
• Est. primary completion date: September 20, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 64 Years

Eligibility

Inclusion Criteria:

• diagnosis of type 2 diabetes

• aged 18-64 years

• patients can walk and cooperative

• body mass index is less than 40 kg / m2

Exclusion Criteria:

Individuals have known lung disease,have undergone any cardiac event or surgery within the past six months, have uncontrolled hypertension, and have diabetic complications such as nephropathy, retinopathy and severe neuropathy.

Related Conditions & MeSH terms

• Diabetes
• Diabetes Mellitus

Intervention

Other:
• Short duration
exercise Short duration high intensity training
• Long duration
exercise Long duration high intensity training

Locations

Country	Name	City	State
Turkey	Hacettepe University	Ankara	State

Sponsors (1)

Lead Sponsor	Collaborator
Hacettepe University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	muscle oxigeneration	It is evaluate with wearable lactate threshold device on gastrocinemius	Change from baseline muscle oxigeneration at 8 weeks
Secondary	The blood glucose consentration	It is evaluate with sample from blood	before and after 8 weeks
Secondary	Functional Exercise capacity	It is evaluated with six minute walk test	before and after 8 weeks
Secondary	Maximal exercise capacity	It is evaluated using with incremental shuttle test	before and after 8 weeks
Secondary	Symptom limited maximal exercise capacity	It is evaluated with cycle ergometer test	before and after 8 weeks
Secondary	Lipit profile-High density lipoprotein cholesterol	High density lipoprotein cholesterol wiil be assesed	before and after 8 weeks
Secondary	Lipit profile- low density lipoprotein cholesterol	low density lipoprotein cholesterol wiil be assesed	before and after 8 weeks
Secondary	Lipit profile- trigliseride	trigliseride wiil be assesed	before and after 8 weeks
Secondary	pulmonary parameter-Forced vital capacity	Forced vital capacity will be evaluated	before and after 8 weeks
Secondary	pulmonary parameter-Forced vital capacity in the first second	Forced vital capacity in the first second will be evaluated	before and after 8 weeks
Secondary	pulmonary parameter-Mid expiratory flow rate	Mid expiratory flow rate will be evaluated	before and after 8 weeks
Secondary	pulmonary parameter-Peak expiratory flow	Peak expiratory flow will be evaluated	before and after 8 weeks
Secondary	Respiratory muscle strength	It is evaluated with mouth pressure	before and after 8 weeks
Secondary	Physical activity level	it is assessed using accelerometer	before and after 8 weeks