The Effect of Dopamine on Diabetic Retinopathy

Status Completed

Clinical Trial Summary

Clinical Trial Description

The purpose of this study is to evaluate the use of electroretinogram (ERG) using a novel handheld system, RETeval, and evaluate contrast sensitivity testing in detecting pre-clinical retinopathy on a tablet device.

Investigators also seek to assess if a medication called Sinemet™ CR can improve the electrical functions of the eye in participants with diabetes mellitus. This study will include a total of 45 participants; 30 with diabetes mellitus and 15 age-matched non-diabetic controls. Participants with diabetes mellitus and electroretinogram (ERG) delays will be randomized to a low or high dose Sinemet™ CT group.

Age-matched controls will not receive Sinemet Ct drug treatment.

The study involves four visits over the course of 4 weeks, each visit consisting of 2-3 hours. Visual testing will be performed at 1 day and 2 weeks following treatment. The drug treatment will be halted and testing repeated again after a 2 week wash-out period. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02706977
Study type	Interventional
Source	Emory University
Contact
Status	Completed
Phase	Phase 1
Start date	January 2016
Completion date	August 15, 2019

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The Effect of Dopamine on Diabetic Retinopathy — Dopamine DR

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms