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Initial Combination of Gemigliptin and Metformin on Microbiota Change — INTESTINE  

Diabetes Clinical Trial

Official title:
Effect of INitial Combination Therapy With GEmigliptin and Metformin on Microbiota Change and Glycemic Control in patientS With Type 2 DIabetes aNd ObEsity (INTESTINE Study)

Clinical Trial Summary

The purpose of this study is to investigate gut microbiota change and glucose lowering effect of initial combination therapy of gemigliptin and metformin compared to glimepiride and metformin in obese patients with type 2 diabetes.

Clinical Trial Description

Obese type 2 diabetes patients who were not treated with anti-diabetic medication within 6 weeks, were randomly assigned to gemigliptin/metformin or sulphonylurea/metformin. After 24 week treatment, gut microbiota composition change, glucose lowering effect, body weight, and gut hormones were compared between two groups. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02609815
Study type Interventional
Source Seoul National University Bundang Hospital
Contact
Status Completed
Phase N/A
Start date November 1, 2015
Completion date March 15, 2021
View Details
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